TITLE

Pharmacogenetics and personalized treatment of type 2 diabetes mellitus

AUTHOR(S)
Beltramo, Dante; Yang, Pablo; Soria, NĂ©stor; Heredia, VerĂ³nica
PUB. DATE
December 2016
SOURCE
International Journal of Diabetes in Developing Countries;Dec2016, Vol. 36 Issue 4, p508
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The articles analyzes the effectiveness and toxicity of hypoglycemic agents and its association with pharmacogenetics factors and genetic variants in people with type 2 diabetes mellitus (T2DM). Hypoglycemic agents discussed include sulfonylureas, meglitinides, and thiazolidinediones. Effect of genetic polymorphisms including KCNJ11 gene, cytochrome P450 enzyme complex (CYP450), and organic cationtransporter 1(OCT1) (SLC22A1 gene) in absorption and metabolism of drugs are discussed.
ACCESSION #
120511403

 

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