TITLE

RND efflux pump mediated antibiotic resistance in Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa: a major issue worldwide

AUTHOR(S)
Puzari, Minakshi; Chetia, Pankaj
PUB. DATE
February 2017
SOURCE
World Journal of Microbiology & Biotechnology;Feb2017, Vol. 33 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Therapeutic failures against diseases due to resistant Gram-negative bacteria have become a major threat nowadays as confirmed by surveillance reports across the world. One of the methods of development of multidrug resistance in Escherichia coli and Pseudomonas aeruginosa is by means of RND efflux pumps. Inhibition of these pumps might help to combat the antibiotic resistance problem, for which the structure and regulation of the pumps have to be known. Moreover, judicious antibiotic use is needed to control the situation. This paper focuses on the issue of antibiotic resistance as well as the structure, regulation and inhibition of the efflux pumps present in Escherichia coli and Pseudomonas aeruginosa.
ACCESSION #
120497557

 

Related Articles

  • French regional surveillance program of carbapenemase-producing Gram-negative bacilli: results from a 2-year period. Pantel, A.; Boutet-Dubois, A.; Jean-Pierre, H.; Marchandin, H.; Sotto, A.; Lavigne, J.-P. // European Journal of Clinical Microbiology & Infectious Diseases;Dec2014, Vol. 33 Issue 12, p2285 

    In February 2011, the CARB-LR group was created as a sentinel laboratory-based surveillance network to control the emergence of carbapenem-resistant Gram-negative bacilli (CR GNB) in a French Southern Region. We report the epidemiological results of a 2-year study. All the Gram-negative bacilli...

  • Treatment of Multidrug-Resistant Gram-Negative Infections in Children. Hsu, Alice J.; Tamma, Pranita D. // Clinical Infectious Diseases;May2014, Vol. 58 Issue 10, p1439 

    Multidrug-resistant gram-negative infections are a growing threat to the pediatric community. In this review, we discuss treatment considerations for infections caused by extended-spectrum β-lactamases, AmpC β-lactamases, and carbapenem-resistant gram-negative organisms in...

  • Effectiveness of Antibiotic-Lock Therapy for Long-term Catheter- Related Bacteremia Due to Gram- Negative Bacilli: A Prospective Observational Study. Funalleras, Gisela; Ferna'ndez-Hidalgo, Nuria; Borrego, Astrid; Almirante, Benito; Planes, Anna Maria; Rodríguez, Dolors; Ruiz, Isabel; Pahissa, Albert // Clinical Infectious Diseases;11/1/2011, Vol. 53 Issue 9, p129 

    A prospective observational study evaluated the effectiveness of combining antibiotic-lock therapy and systemic antibiotics for Gram-negative bacilli long-term catheterrelated bacteremia. In 46 uncomplicated episodes, the most frequently isolated microorganisms were Pseudomonas aeruginosa (15),...

  • Chemical resistance of the gram-negative bacteria to different sanitizers in a water purification system. Mazzola, Priscila G.; Martins, Alzira M.S.; Penna, Thereza C.V. // BMC Infectious Diseases;2006, Vol. 6 Issue 1, p131 

    Background: Purified water for pharmaceutical purposes must be free of microbial contamination and pyrogens. Even with the additional sanitary and disinfecting treatments applied to the system (sequential operational stages), Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas...

  • Colicin-like bacteriocins as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Brown, Carla L.; Smith, Karen; McCaughey, Laura; Walker, Daniel // Biochemical Society Transactions;Dec2012, Vol. 40 Issue 6, p1549 

    The emergence of pan-resistant strains of Gram-negative pathogens and the ability of many bacteria to form multidrug-resistant biofilms during chronic infection poses the grave threat of bacterial infections that are truly untreatable with our current armoury of antibiotics. Despite obvious...

  • Risk factors for mortality in patients with nosocomial Gram-negative rod bacteremia. KARAKOC, C.; TEKIN, R.; YEŞILBAĞ, Z.; CAGATAY, A. // European Review for Medical & Pharmacological Sciences;Apr2013, Vol. 17 Issue 7, p951 

    BACKGROUND: The percentage of hospital-acquired bloodstream infections associated with Gram-negative bacilles has decreased during last decade but it is still a major cause of morbidity and mortality. OBJECTIVES: The aim of this study was to determine the outcome of Gram-negative rod (GNR)...

  • Emergence of CTX-M-15 producing E. coli 025b-ST131 clone in a tertiary care hospital of Bangladesh. BEGUM, Nurjahan; SHAMSUZZAMAN, S. M. // Malaysian Journal of Pathology;Dec2016, Vol. 38 Issue 3, p241 

    Background: Extended-spectrum (3-lactamase (ESBL) producing uropathogens has become prevalent worldwide. E. coli O25b-ST131 clone, associated with blaCTX-M-15, has been reported from many parts of the world and is frequently associated with multidrug resistance. Thus far, there are no reports...

  • Colistin-resistant Escherichia coli clinical isolate harbouring the mcr-1 gene in Ecuador. ORTEGA-PAREDES, D.; BARBA, P.; ZURITA, J. // Epidemiology & Infection;Oct2016, Vol. 144 Issue 14, p2967 

    Colistin resistance mediated by the mcr-1 gene has been reported worldwide, but to date not from the Andean region, South America. We report the first clinical isolate of Escherichia coli harbouring the mcr-1 gene in Ecuador. The strain was isolated from peritoneal fluid from a 14-year-old male...

  • Brucellosis: Endemic and re-emerging zoonosis. Shimshony, Arnon // Infectious Disease News;Sep2013, Vol. 26 Issue 9, p50 

    The article reports on the significant increase in the number of suspected brucellosis cases in humans as reported by the Syrian Ministry of Health and the World Health Organization (WHO) Early Warning Alert and Response System, which the United Nation's Food and Agriculture Organization...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics