TITLE

Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?

AUTHOR(S)
Magalhães, Paulo; de Andrés, Fernando; Falcão, Amílcar; Lerena, Adrián L.; Alves, Gilberto
PUB. DATE
August 2016
SOURCE
Journal of Pharmacy & Pharmaceutical Sciences;2016, Vol. 19 Issue 4, p520
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
120495527

 

Related Articles

  • Assessment of CYP2B6 activity in rats: A cocktail study with bupropion alone and in combined with tolbutamide. Ren-ai Xu; Lufeng Hu; Zhe Wang; Xiaoxiang Du; Haiyan Zhu; Xiuhua Zhang // Pakistan Journal of Pharmaceutical Sciences;Jul2013, Vol. 26 Issue 4, p813 

    A "cocktail"of numerous probe drugs to assess the metabolic activity of the corresponding cytochrome P450 enzymes requires that there is no problem of interaction among them. Some interactions among probe drugs can appear and may affect the rate of biotransformation of other ones. To develop a...

  • Evaluation of CYP2C9 Activity in Rats: Use of Tolbutamide Alone and in Combined with Bupropion. Xiangjun Qiu; Jijun Song; Hongchang Yuan; Yi Hou; Xiaofeng Pan; Ren-ai Xu // Iranian Journal of Pharmaceutical Research;Spring2014, Vol. 13 Issue 2, p635 

    A "cocktail"of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was aimed on the influence of...

  • Drug Cocktail Optimization in Chemotherapy of Cancer. Preissner, Saskia; Dunkel, Mathias; Hoffmann, Michael F.; Preissner, Sarah C.; Genov, Nikolai; Rong, Wen Wei; Preissner, Robert; Seeger, Karlheinz // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    Background: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP). Furthermore, a number of important chemotherapeutic drugs...

  • Cytochrome P450 enzyme inhibition can result in drug interactions. Harrigan, Peter // Dermatology Times;Nov98, Vol. 19 Issue 11, p11 

    Reports that inhibition of cytochrome P450 enzymes can result in mild to severe drug interactions. Activity of P450 enzymes; Antifungal drug interactions; Drug interaction education.

  • Effect of Recombinant Human Thymosin-a1, an Immuno-Modulating Peptide with 28 Amino Acids, on the Activity of Cytochrome P450s. Wang, Bing; Fan He; Yu Lin; Min Huang; Shu-Feng Zhou // Drug Metabolism Letters;Aug2007, Vol. 1 Issue 3, p199 

    There is an increasing application of protein/peptide drugs in the treatment of various diseases such as cancer and autoimmune diseases in clinical settings. However, data is scant on the potential for modulation of cytochrome P450s (CYPs) by these protein/peptide drugs. In this study, we...

  • Possible role of rat liver NADPH cytochrome P-450 reductase in the detoxication of DDT to DDD. Zaidi, S. // Bulletin of Environmental Contamination & Toxicology;Aug1987, Vol. 39 Issue 2, p327 

    The article presents a study of the possible influence of rat liver NADPH cytochrome P-450 reductase in the detoxication of DDT and dichlorodiphenyldichloroethane (DDD). The study uses gas chromatography (GC) to measure the enzyme activity for DDT and DDD detoxication. It suggests that DDT and...

  • Influence of Itraconazole on the antidiabetic effect of sulfonylureas in alloxan induced diabetic rats. Geetha, K. M.; Sireesha, K.; Murugan, V. // Journal of Pharmacy Research;2012, Vol. 5 Issue 7, p3889 

    Drugs are used in the prevention and treatment of symptoms and diseases but the drug-drug interactions are one of the major problems in multi-drug therapy. The present study was aimed to investigate the possible drug interaction with Itraconazole when administered as combination treatment in...

  • SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450. Li Li; Dong-Qing Wei; Jing-Fang Wang; Kuo-Chen Chou // Protein & Peptide Letters;Jan2012, Vol. 19 Issue 1, p57 

    Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was developed for predicting human...

  • Fishing for Allergens Hiding as Prohaptens. Mukhtar, Hasan; Afaq, Farrukh; Matsui, Mary S. // Journal of Investigative Dermatology;May2007, Vol. 127 Issue 5, p992 

    Enzymes of the cytochrome P450 (CYP) superfamily are the most versatile and important class of drug-metabolizing enzymes, involved in the metabolism of xenobiotics to which human skin is exposed. Bergström et al. used a recombinant human CYP cocktail in ratios that simulate those found in...

  • Therapeutic Protein–Drug Interactions and Implications for Drug Development. Huang, S-M.; Zhao, H.; Lee, J-I.; Reynolds, K.; Zhang, L.; Temple, R.; Lesko, L. J. // Clinical Pharmacology & Therapeutics;Apr2010, Vol. 87 Issue 4, p497 

    Many intrinsic and extrinsic factors can affect an individual patient's drug exposure and response.1 The US Food and Drug Administration (FDA) has published a number of guidances that recommend how and when to evaluate these factors during drug development.2 The most recent FDA draft guidance on...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics