TITLE

Nonalcoholic fatty liver disease is associated with low-grade albuminuria in Chinese adults (change not displayed)

AUTHOR(S)
Lin, L.; Lu, J.; Huang, X.; Ding, L.; Huang, Y.; Wang, P.; Peng, K.; Zhang, D.; Xu, M.; Chen, Y.; Bi, Y.; Wang, W.; Xu, Y.
PUB. DATE
November 2016
SOURCE
QJM: An International Journal of Medicine;Nov2016, Vol. 109 Issue 11, p737
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Nonalcoholic fatty liver disease (NAFLD) was associated with higher risk of cardiovascular disease (CVD). Lowgrade albuminuria was recognized as an early indicator of CVD. Epidemiological studies investigating the association between NAFLD and low-grade albuminuria were limited. Aim: To determine whether NAFLD is independently associated with the presence of low-grade albuminuria in Chinese adults. Design: A cross-sectional community-based population study was performed in 8270 Chinese adults aged 40 years or older. Methods: A first-voided early morning spot urine sample was obtained for urinary albumin and creatinine measurements. The highest quartile of urinary albumin-to-creatinine ratio was defined as low-grade albuminuria, after excluding the participants with micro- or macroalbuminuria. NAFLD was diagnosed by using ultrasonography findings after the exclusion of alcohol abuse and other liver diseases. Results: The prevalence of low-grade albuminuria was significantly higher in participants with NAFLD than in those without NAFLD (33.6% vs. 21.3% in men and 30.4% vs. 22.8% in women, respectively). Multivariate-adjusted logistic regression analysis revealed that NAFLD was significantly associated with increased odds ratio of low-grade albuminuria in men (odds ratio, 1.47; 95% CI, 1.16-1.87) after adjusting for multiple confounders. The significant association was not detected in women. Conclusions: NAFLD was significantly associated with an increased risk of present low-grade albuminuria in middle-aged and elderly Chinese men.
ACCESSION #
120489658

 

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