Metastatic Melanoma in the Femur -- Case Report with Review of Literature: a Pathologist's Point of View

COSTACHE, Mariana; STOICA, Alexandra; CONTOLENCO, Andreea; COSTACHE, Diana; CIRSTOIU, Catalin; SIMIONESCU, Olga; GEORGE, Simion
January 2014
Maedica - a Journal of Clinical Medicine;2014, Vol. 9 Issue 1, p62
Academic Journal
Case Study
The aim of this case report was to evaluate the histopathological characteristics on a patient with metastases in the femur from malignant melanoma. A review from the literature is also mentioned. We present a case of metastatic malignant melanoma in the femur with known primary site in a 44-year-old-female. Diagnosis was confirmed by histopathology. Malignant melanoma is a cancer that may metastasise in the skeleton. However most of bone metastases are found in the axial skeleton and they rarely involve the femur, as in our case. Only a few case reports are published in the literature. Clinicians must be aware of the varied clinical manifestations of disseminated malignant melanoma. The diagnosis for metastatic malignant melanoma is confirmed due to pathological examination. Immunohistochemical study is useful in diagnosis, mainly when malignant melanoma is poorly differentiated.


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