TITLE

Liver function tests and hyperbilirubinemia in adult patients undergoing open heart surgery

AUTHOR(S)
Yuksel, Ahmet; Tuydes, Oktay; Minbay, Hakan; Bicer, Murat; Saba, Davit
PUB. DATE
October 2016
SOURCE
Journal of Turgut Ozal Medical Center;2016, Vol. 23 Issue 4, p357
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: The effects of cardiac surgery and cardiopulmonary bypass on postoperative liver function tests and hyperbilirubinemia in adult patients undergoing open heart surgery were studied, and related literature was reviewed and compared with our results. Materials and Methods: Between January 2013 and March 2013, forty adult patients who undergone open heart surgery were included in this study. Patients were prospectively evaluated in regard of the alterations in liver function tests, the risk factors that effects these alterations; their effects on morbidity and mortality after cardiopulmonary bypass were evaluated and were compared with recent literature results. Patients' preoperative and postoperative 0, 1, 2, 7 and 14th day liver function tests and bilirubin levels were measured. Results: Blood total protein, albumin, total cholesterol, ALP levels were fallen remarkably on postoperative day 1, followed with gradual increase ultimately reaching preoperative levels, and these alterations were statistically significant. The total bilirubin, AST, ALT, LDH, GGT, INR levels were elevated in the early postoperative period, and fell to normal levels later on. All increases of the enzymes were statistically significant except ALT. In our study, only 7 patients displayed hyperbilirubinemia. When patients with hyperbilirubinemia were compared with patients who did not have hyperbilirubinemia, preoperative albumin and CK levels were found to be risk factors for hyperbilirubinemia. Conclusion: By studying the effects of heart and cardiopulmonary bypass surgery on the liver and the probable risk factors, we believe that by detecting the patients with high risk of hepatic failure required measures should be taken preoperatively, perioperative patient care quality improved and any complication can be fixed appropriately. To understand the reasons and prevention of perioperative hepatic failure, we think that the studies should be performed with larger patient groups with longer periods.
ACCESSION #
120449206

 

Related Articles

  • Adjustment of sweep gas flow during cardiopulmonary bypass. Karabulut, Hasan; Toraman, Fevzi; Tarcan, Sümer; Demirhisar, Önder; Alhan, Cem // Perfusion;Sep2002, Vol. 17 Issue 5, p353 

    Cardiopulmonary bypass (CPB) is one of the major tools of cardiac surgery. However, no clear data are available for the ideal value of sweep gas flow to oxygenator during CPB. The aim of this study was to determine the best value for sweep gas flow during CPB. Thirty patients undergoing isolated...

  • Erratum to: Cerebral Near-Infrared Spectroscopy Correlates to Vital Parameters During Cardiopulmonary Bypass Surgery in Children. Menke, Jan; Möller, Gerhard // Pediatric Cardiology;Aug2014, Vol. 35 Issue 6, p1082 

    A correction to the article "Cerebral Near-Infrared Spectroscopy Correlates to Vital Parameters During Cardiopulmonary Bypass Surgery in Children" that was published in the previous issue is presented.

  • Leukocyte filtration in cardiac surgery: a review. Matheis, G.; Scholz, M.; Simon, A.; Dzemali, O.; Moritz, A. // Perfusion;Sep2001, Vol. 16 Issue 5, p361 

    Leukocyte filtration has evolved as an important technique in cardiac surgery with cardiopulmonary bypass to prevent pathogenic effector functions mediated by activated leukocytes. The underlying mechanisms that result in an improvement of laboratory variables as well as clinical outcome are not...

  • Aprotinin: An Update of its Pharmacology and Therapeutic Use in Open Heart Surgery and Coronary Artery Bypass Surgery. Peters, D.C.; Noble, S. // Drugs;Feb1999, Vol. 57 Issue 2, p233 

    Cardiopulmonary bypass (CPB) is associated with defective haemostasis which results in bleeding and the requirement for allogenic blood product transfusions in many patients undergoing open heart surgery (OHS) and/or coronary artery bypass graft surgery (CABG) with CPB. Conservation of blood has...

  • Complications after cardiopulmonary bypass.  // American Family Physician;10/1/1995, Vol. 52 Issue 5, p1531 

    Reports on a study from the May 1995 issue of the `Annals of Surgery,' by Spotnitz and colleagues who reviewed the factors associated with complication of cardiopulmonary bypass surgery. Relation of general surgical complications of cardiopulmonary bypass to low cardiac output; Implementation of...

  • Profound haemodilution during normothermic cardiopulmonary bypass influences neither gastrointestinal permeability nor cytokine release in coronary artery bypass graft surgery. Berger, K.; Sander, M.; Spies, C. D.; Weymann, L.; Bühner, S.; Lochs, H.; Wernecke, K.-D.; Von Heymann, C. // BJA: The British Journal of Anaesthesia;Oct2009, Vol. 103 Issue 4, p511 

    Background: Cardiopulmonary bypass (CPB) impairs intestinal barrier function and induces systemic inflammation after cardiac surgery. The objective of this study was to evaluate the effect of profound haemodilution (haematocrit 19–21%) during normothermic CPB on gastrointestinal...

  • Early experience with robotic aortic valve replacement Folliguet, Thierry A.; Vanhuyse, Fabrice; Konstantinos, Zanis; Laborde, François // European Journal of Cardio-Thoracic Surgery;Jul2005, Vol. 28 Issue 1, p172 

    Abstract: We report our initial experience with aortic valve replacement using robotic assistance. All procedures were performed with peripheral cardiopulmonary bypass, transthoracic aortic cross-clamp, and antegrade cold crystalloid cardioplegia. One or two ports and a 5-cm intercostal incision...

  • Total arterial revascularisation: effect of avoiding cardiopulmonary bypass on in-hospital mortality and morbidity in a propensity-matched cohort Pandey, Ragini; Grayson, Antony D.; Pullan, D. Mark; Fabri, Brian M.; Dihmis, Walid C. // European Journal of Cardio-Thoracic Surgery;Jan2005, Vol. 27 Issue 1, p94 

    Abstract: Objective: The combination of total arterial revascularisation and avoidance of cardiopulmonary bypass may provide additional benefits to patients receiving complete arterial grafting with cardiopulmonary bypass. We performed a propensity-matched cohort study of complete arterial...

  • Extensive Thoracic Organ Resection for a Patient Who Harbors Spindle Cell Sarcoma. Withurawanit, Wichaya; Cherntanomwong, Piya // Thai Journal of Surgery;Jan-Jun2009, Vol. 30 Issue 1/2, p22 

    The article presents a case study of a 27-year-old female patient with spindle cell sarcoma of the pericardium who underwent a thoracic surgery. It states that the patient has no history of treatment and due to her worsening symptoms, she decided to have a surgery at Cardiothoracic Surgical...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics