Cellular senescence in cancer treatment: friend or foe?

Kahlem, Pascal; Dörken, Bernd; Schmitt, Clemens A.; Pelicci, Pier Giuseppe
January 2004
Journal of Clinical Investigation;Jan2004, Vol. 113 Issue 2, p169
Academic Journal
Damage to DNA, the prime target of anticancer therapy, triggers programmed cellular responses. In addition to apoptosis, therapy-mediated premature senescence has been identified as another drug-responsive program that impacts the outcome of cancer therapy. Here, we discuss whether induction of senescence is a beneficial or, rather, a detrimental consequence of the therapeutic intervention.


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