Bone marrow potential
Tags: BLOOD platelets; STEM cells; BONE marrow cells; IMMUNE system; MEDICINE -- Research
Related Articles
- Immunology: Blood lines redrawn. Graf, Thomas // Nature;4/10/2008, Vol. 452 Issue 7188, p702
The article focuses on the central aspect of blood-cell differentiation. The main components of the blood are red cells, whites cells and platelets. These were produced from the haematopoietic stem cells as a common source. On the other hand, the white cells or the leukocytes functions as an...
- Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction -- a cardiovascular magnetic resonance tagging study. Hopp, Einar; Lunde, Ketil; Solheim, Svein; Aakhus, Svend; Arnesen, Harald; Forfang, Kolbj�rn; Edvardsen, Thor; Smith, Hans-J�rgen // Journal of Cardiovascular Magnetic Resonance (BioMed Central);2011, Vol. 13 Issue 1, p22
Background: Trials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium. This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial (ASTAMI) explored global and regional myocardial function after intracoronary injection of...
- Essential Thrombocythemia. Sanchez, Steven; Ewton, April // Archives of Pathology & Laboratory Medicine;Aug2006, Vol. 130 Issue 8, p1144
Context.�Essential thrombocythemia (ET) is a chronic myeloproliferative disorder (CMPD) characterized predominately by thrombocytosis and abnormal megakaryocyte proliferation. The current diagnostic criteria require a combination of clinical, histologic, and cytogenetic data. The diagnosis...
- Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques. Derdouch, Sonia; Gay, Wilfried; N�gre, Didier; Prost, St�phane; Le Dantec, Mikael; Delache, Beno�t; Auregan, Gwenaelle; Andrieu, Thibault; Leplat, Jean-Jacques; Cosset, Fran�ois-Lo�c; Le Grand, Roger // Retrovirology;2008, Vol. 5, Special section p1
Background: Prolonged, altered hematopoietic reconstitution is commonly observed in patients undergoing myeloablative conditioning and bone marrow and/or mobilized peripheral blood-derived stem cell transplantation. We studied the reconstitution of myeloid and lymphoid compartments after the...
- Comment on CD34+ selected hematopoietic stem cell (HSC) not preceded by any immunosuppressive therapy as effective treatment of graft failure. Lang, P.; Niethammer, D.; Bader, P.; Greil, J. // Bone Marrow Transplantation;Mar2005, Vol. 35 Issue 5, p522
This article presents a response to the study, conducted by scientist G. Milone and colleagues, which states that selected hematopoietic stem cell (HSC) not preceded by any immunosuppressive therapy is an effective treatment of graft failure. The scientists refer to a case of a 12-year-old boy...
- AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. Takeshita, M.; Ichikawa, M.; Nitta, E.; Goyama, S.; Asai, T.; Ogawa, S.; Chiba, S.; Kurokawa, M. // Leukemia (08876924);Jun2008, Vol. 22 Issue 6, p1241
The t(3;21) chromosomal translocation seen in blastic crisis of chronic myeloid leukemia and secondary leukemias results in a formation of a chimeric protein AML1-Evi-1, which suppresses wild-type AML1 function. Loss of AML1 function causes expansion of hematopoietic progenitor cells, whereas it...
- Hematopoietic Stem Cells (HSC). Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p280
A definition of the term "hematopoietic stem cells" (HSC) is presented. It refers to a population of self-renewing cells committed to blood cell formation. Stem cells have the capacity to repopulate the blood forming and immune systems in irradiated hosts. HSC differentiate and generate...
- Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Ott, Marion G.; Schmidt, Manfred; Schwarzwaelder, Kerstin; Stein, Stefan; Siler, Ulrich; Koehl, Ulrike; Glimm, Hanno; K�hlcke, Klaus; Schilz, Andrea; Kunkel, Hana; Naundorf, Sonja; Brinkmann, Andrea; Deichmann, Annette; Fischer, Marlene; Ball, Claudia; Pilz, Ingo; Dunbar, Cynthia; Yang Du; Jenkins, Nancy A.; Copeland, Neal G. // Nature Medicine;Apr2006, Vol. 12 Issue 4, p401
Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received gene therapy after nonmyeloablative bone marrow conditioning for the treatment of X-linked chronic granulomatous disease...
- Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells. Walkley, Carl R.; Fero, Matthew L.; Chien, Wei-Ming; Purton, Louise E.; McArthur, Grant A. // Nature Cell Biology;Feb2005, Vol. 7 Issue 2, p172
Haematopoietic stem cells (HSCs) are capable of shifting from a state of relative quiescence under homeostatic conditions to rapid proliferation under conditions of stress. The mechanisms that regulate the relative quiescence of stem cells and its association with self-renewal are unclear, as is...
