TITLE

Antibiotic Resistance Pattern of Extended-Spectrum Beta-Lactamases-Producing Klebsiella pneumoniae Clinical Isolates from Zahedan, Southeast Iran

AUTHOR(S)
Shahraki-Zahedani, Shahram; Moghadampour, Mehdi; Bokaeian, Mohammad; Ansari-Moghaddam, Alireza
PUB. DATE
November 2016
SOURCE
Zahedan Journal of Research in Medical Sciences;Nov2016, Vol. 18 Issue 11, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Resistance to various classes of antibiotics iscommonamong extended-spectrum beta-lactamases (ESBLs)-producing bacteria. Objectives: To determine the antibiotic resistance pattern of ESBLs-producing K. pneumoniae clinical isolates from Zahedan. Methods: In this sectional-descriptive study, susceptibility of 51 ESBLs-producing K. pneumoniae isolates to 18 antimicrobial agents was determined. Results: All isolates were resistant to cefotaxime, cefpodoxime and amoxicillin as well as susceptible to colistin sulfate. Also, most isolates were resistant to trimethoprim/sulfamethoxazole and aztreonam. Conclusions: Our findings demonstrated that the rate of resistance to beta-lactams, sulfonamides, tetracyclines, aminoglycosides and fluoroquinolones in ESBLs-producing K. pneumoniae isolates is high in Zahedan.
ACCESSION #
119714566

 

Related Articles

  • A Method for Generation Phage Cocktail with Great Therapeutic Potential. Jingmin Gu; Xiaohe Liu; Yue Li; Wenyu Han; Liancheng Lei; Yongjun Yang; Honglei Zhao; Yu Gao; Jun Song; Rong Lu; Changjiang Sun; Xin Feng // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Background: Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant variants after phage treatment limited its therapeutic application. Methodology/Principal Findings: In this study, an approach, named...

  • A Method for Generation Phage Cocktail with Great Therapeutic Potential. Jingmin Gu; Xiaohe Liu; Yue Li; Wenyu Han; Liancheng Lei; Yongjun Yang; Honglei Zhao; Yu Gao; Jun Song; Rong Lu; Changjiang Sun; Xin Feng // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Background: Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant variants after phage treatment limited its therapeutic application. Methodology/Principal Findings: In this study, an approach, named...

  • Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA. Wang, Qun; Chen, Yan; Cvitkovic, Romana; Pennini, Meghan E.; Chang, Chew shun; Pelletier, Mark; Bonnell, Jessica; Koksal, Adem C.; Wu, Herren; Dall’Acqua, William F.; Stover, C. Kendall; Xiao, Xiaodong // PLoS ONE;1/20/2017, Vol. 12 Issue 1, p1 

    Antibody therapy against antibiotics resistant Klebsiella pneumoniae infections represents a promising strategy, the success of which depends critically on the ability to identify appropriate antibody targets. Using a target-agnostic strategy, we recently discovered MrkA as a potential antibody...

  • Prevalence and Antimicrobial Susceptibility of Hypervirulent Klebsiella pneumoniae Isolates in China. Zhang, Youjiang; Ma, Yanning; Ye, Liyan; Luo, Yanping; Yang, Jiyong // Clinical Infectious Diseases;May2014, Vol. 58 Issue 10, p1493 

    A letter to the editor is presented in response to the article "Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China" by W. Li in the previous issue.

  • ESBL DETERMINATION AND ANTIBACTERIAL DRUG RESISTANCE PATTERN OF KLEBSIELLA PNEUMONIAE AMONGST PATIENTS AT PIMS ISLAMABAD. Khan, Jafar; Naz, Noor; AbdEl-Salam, Naser M.; Nayab; Tabassum, Anum; Hussain, Hidayat; Ullah, Riaz // African Journal of Traditional, Complementary & Alternative Medi;2015 Special Issue, Vol. 12, p70 

    Background: A number of life threatening infections due to various bacterial pathogens are major cause of death in Pakistan. In a situation like the other developing countries, there is a general increase in the drug resistance due to the irrational use of the antibiotics. The present study was...

  • In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPC-producing Klebsiella pneumoniae bloodstream isolates. Gaibani, Paolo; Lombardo, Donatella; Lewis, Russell E.; Mercuri, Marcella; Bonora, Sonia; Landini, Maria Paola; Ambretti, Simone // Journal of Antimicrobial Chemotherapy (JAC);Jul2014, Vol. 69 Issue 7, p1856 

    Objectives Combination therapy is recommended for the treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp), but the optimal regimen for colistin-resistant strains is unknown. We compared the synergistic activity and post-antibiotic effect (PAE) of colistin in combination with other...

  • Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics. Malik, Muhammad; Li, Liping; Zhao, Xilin; Kerns, Robert J.; Berger, James M.; Drlica, Karl // Journal of Antimicrobial Chemotherapy (JAC);Dec2014, Vol. 69 Issue 12, p3227 

    Background One way to address the growing problem of antimicrobial resistance is to revive old compounds that may have intrinsic lethal activity that is obscured by protective factors. Bicyclomycin is an old inhibitor of the Rho transcription terminator that by itself shows little rapid lethal...

  • Detection of OXA-1 β-Lactamase Gene of Klebsiella pneumoniae from Blood Stream Infections (BSI) by Conventional PCR and In-Silico Analysis to Understand the Mechanism of OXA Mediated Resistance. Sugumar, Madhan; Kumar, K. M.; Manoharan, Anand; Anbarasu, Anand; Ramaiah, Sudha // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Klebsiella pneumoniae strains producing extended-spectrum β-lactamases (ESBL) exhibit resistance to antibiotic classes. The production of ESBLs (TEM-1, TEM-2, SHV-1, OXA-1) results in resistance to ampicillin, ticarcillin, piperacillin and cephalosporins. High levels of β-lactamases leads...

  • Assessment of antibiotic resistance in Klebsiella pneumoniae exposed to sequential in vitro antibiotic treatments. Jeongjin Kim; Jo, Ara; Chukeatirote, Ekachai; Juhee Ahn // Annals of Clinical Microbiology & Antimicrobials;12/9/2016, p1 

    Background: Bacteria treated with different classes of antibiotics exhibit changes in susceptibility to successive antibiotic treatments. This study was designed to evaluate the influence of sequential antibiotic treatments on the development of antibiotic resistance in Klebsiella pneumoniae...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics