TITLE

The potential risks of abnormal transmission of mtDNA through assisted reproductive technologies

AUTHOR(S)
St. John, Justin C.; Lloyd, Rhiannon; El Shourbagy, Shahinaz
PUB. DATE
January 2004
SOURCE
Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jan2004, Vol. 8 Issue 1, p34
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The recent introduction of more invasive assisted reproductive techniques offers the possibility to provide a wider treatment profile to patients. However, some of these technologies are of considerable concern as they are fraught with the possible transmission of genetic abnormalities to the offspring they create. To date, much analysis of these technologies has been conducted at the chromosomal DNA level. While some analysis has been conducted on the extranuclear, mitochondrial genome (mtDNA), this has been mainly descriptive. In the vast majority of cases, it appears that mtDNA is maternally inherited. The impact that leakage of sperm mtDNA transmission might have for the offspring is discussed in the light of the recent identification of sperm mtDNA presence in a patient with mtDNA disease. The implications of introducing donor mtDNA into a recipient oocyte through both cytoplasmic and nuclear transfer are also discussed. Again, the implications for offspring survival are discussed and suggestions made as to why the techniques might provide valuable insights into mtDNA transmission, replication and transcription. In order to be confident that patients and their offspring are being offered safe treatment, it is argued that potentially some of these treatments may be of considerable benefit in the future but significant scientific research is required before these treatments can be effectively employed in the clinic.
ACCESSION #
11968382

 

Related Articles

  • Symposium: Mitochondria and human conception. Cummins, Jim M. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jan2004, Vol. 8 Issue 1, p14 

    Provides brief information on mitochondria and human fertilization. Myth about fertilization and prevention of inheritance of paternal mitochondrial DNA (mtDNA); Details of a research concept based on molecular palaeontology using mtDNA.

  • Use of Intracytoplasmic Sperm Injection in In Vitro Fertilization Cycles with Failed or Poor Fertilization. Kipersztok, Simon; Williams, R. Stan; Rhoton-Vlasak, Alice S.; Li, Man; Drury, Kenneth C. // Reproductive Technologies;Nov2001, Vol. 10 Issue 6, p311 

    When fertilization is poor or fails, intracytoplasmic sperm injection (ICSI) can be performed in an attempt to overcome the fertilization failure and thus obtain embryos that can be transferred and implanted. Between February 1996 and September 2000, 18 infertile couples went through 25...

  • Study of the in vitro maturation of mouse oocytes induced by microinjection of maturation... Nakano, Hideyuki; Kubo, Harumi // Journal of Assisted Reproduction & Genetics;Jan2000, Vol. 17 Issue 1, p67 

    Studies the induction of maturation of mammalian oocytes by microinjection of extracted maturation promoting factor (MPF). Purification of MPF; Preparation of demembranated sperm nuclei; Collection and culture of immature mouse oocytes; Assay of MPF activity in a cell-free system.

  • New outlooks on IVF spermatozoa. Edwards, R.G. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jul/Aug2002, Vol. 5 Issue 1, p89 

    Presents information on several research regarding the use of spermatozoa in assisted conception. Result of a study on potential changes in spermatozoa during a prolonged period in the uterus; Details on a report dealing with sperm donation and the rights of offspring to know details of their...

  • Fluid chip directs wandering sperm.  // New Scientist;10/22/2005, Vol. 188 Issue 2522, p29 

    This article focuses on a study related to sperm. Men may hate asking for directions, or so the stereotype goes, but it seems sperm are happy to be told where to swim. Microfluidics, the study of how fluids move at the microscopic level, is set to improve IVF treatment for couples in which the...

  • Infertility--X or Y factors. Lutz, Brobson // New Orleans Magazine;Jan2001, Vol. 35 Issue 4, p30 

    Presents information on in-vitro fertilization.

  • Origin stories revisited: IVF as an anthropological project. Franklin, Sarah // Culture, Medicine & Psychiatry;Dec2006, Vol. 30 Issue 4, p547 

    The author reflects on IVF as an anthropological project and the classic concerns of anthropology. The feminist scholars perceived IVF as all forms of imitation, which assisted procreation. An overview of IVF enabled conception upsetting the balance between nature-culture polarity is offered....

  • Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI. B. Heindryckx; J. Van der Elst; P. De Sutter; M. Dhont // Human Reproduction;Aug2005, Vol. 20 Issue 8, p2237 

    BACKGROUND: Failed fertilization occurs in 23% of ICSI cycles and is mainly due to lack of oocyte activation. Heterologous ICSI of patient's sperm in mouse oocytes allows discrimination between sperm- and oocyte-related aetiologies of activation failure. Assisted oocyte activation (AOA) by...

  • The Mitochondrial DNA Mutation (ΔmtDNA[sup 5286]) in Human Oocytes: Correlation with Age and IVF Outcome. Yesodi, Vered; Yaron, Yuval; Lessing, Joseph B.; Amit, Ami; Ben-Yosef, Dalit // Journal of Assisted Reproduction & Genetics;Feb2002, Vol. 19 Issue 2, p60 

    Purpose: To evaluate the correlation between the presence of a newly described mitochondrial DNA (mtDNA) mutation (ΔmtDNAS[sup 5286]), patients' age, and in vitro fertilization (IVF) outcomes. Method. The presence of ΔmtDNA[sup 5286] was analyzed by nested-primer PCR in 224 unfersilized...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics