TITLE

Receptorul și rolurile gonadotropinei corionice umane în sarcină

AUTHOR(S)
Bohîlțea, Roxana; Cîrstoiu, Monica; Ionescu, Cringu; Rădoi, Viorica; Botea, Robert; Vlădăreanu, Simona
PUB. DATE
January 2016
SOURCE
Ginecologia.ro;2016, Vol. 4 Issue 11, p22
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
Receptors for human chorionic gonadotropin (hCG) are found in the gonads expressed by the theca cells, interstitial cells, differentiated granulosa and lutheal cells, in the endometrial epithelium, myometrium and tubal mucosa, in the breast tissue, in the endothelium and smooth muscle of the uterine artery, in the cervix, thyroid, retina and skin tissue, on lymphocytes, macrophages, neuroendocrine cells, Leydig cells, seminal vesicles and prostate cells, and are present in a series of fetal vital organs. In pregnancy, human chorionic gonadotropin, a glycoprotein which has almost the same structure as the pituitary luteinizing hormone (LH), is one of the earliest products of the cells forming the embryo and can be considered one of the first signals elaborated by the embryo; it is involved in maintaining the corpus luteum, in implantation process, in immunomodulation, placental morphogenesis and function, as well as fetal growth and differentiation. Initially, immature trophoblast cells secrete β-hCG units, than in later pregnancy, complete αβ hCG is secreted by the trophoblast cells of vSTB fenotype, hCG secretion having a predictible pattern during a successful pregnancy. The hormone is an ideal marker in the diagnosis and monitoring of early intrauterine pregnancy and ectopic pregnancy, gestational trophoblastic disease, fetal aneuploidy, and placental dysfunction.
ACCESSION #
118053710

 

Related Articles

  • Outbound. Umans, Kate // Crazyhorse;Fall2004, Issue 66, p92 

    Presents the poem "Outbound," by Kate Umans.

  • Ribotoxin genes in isolates of Aspergillus section Clavati. Robert Samson // Antonie van Leeuwenhoek;Oct2008, Vol. 94 Issue 3, p481 

    Abstract  Ribotoxins are ribosome inactivator proteins with high specificity against the sarcin/ricin domain of the 28S ribosomal RNA. We examined the presence of ribotoxin genes in isolates of species recently assigned to Aspergillus section Clavati using specific primer pairs. All...

  • A deimmunised form of the ribotoxin, a-sarcin, lacking CD4+ T cell epitopes and its use as an immunotoxin warhead. Jones, Tim D.; Hearn, Arron R.; Holgate, Robert G. E.; Kozub, Dorota; Fogg, Mark H.; Carr, Francis J.; Baker, Matthew P.; Lacadena, Javier; Gehlsen, Kurt R. // PEDS: Protein Engineering, Design & Selection;Nov2016, Vol. 29 Issue 11, p531 

    Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. a-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phosphodiester bond in the sarcin-ricin loop of the...

  • Monologue of the Debtor. Umans, Kate // Crazyhorse;Fall2004, Issue 66, p94 

    Presents the poem "Monologue of the Debtor," by Kate Umans.

  • JEMMY BUTTON.  // Kirkus Reviews;2/15/2013, Vol. 81 Issue 4, p67 

    The article reviews the book "Jemmy Button," by Jennifer Uman.

  • Effect ofN- andC-terminal deletions on the RNAN-glycosidase activity and the antigenicity of karasurin-A, a ribosome-inactivating protein fromTrichosanthes kirilowiivar.japonica. Toshiya Kondo; Satoko Kurihara; Takafumi Yoshikawa; Hajime Mizukami // Biotechnology Letters;Dec2004, Vol. 26 Issue 24, p1873 

    Karasurin-A, from root tubers ofTrichosanthes kirilowiivar.japonica, is a type I ribosome-inactivating protein (RIP) that displays activity of RNAN-glycosidase to remove an adenine in the conserved sarcin/ricin loop of the largest RNA in the ribosome. We expressed recombinant proteins of...

  • Milking and Scratching: Hand-Made Films by Naomi Uman. Rees, Stephen // Library Journal;6/15/2006, Vol. 131 Issue 11, p112 

    This article presents a review of the motion picture "Milking and Scratching: Hand-Made Films by Naomi Uman," by director Naomi Uman.

  • Recent Progress in Medicinal Investigations on Trichosanthin and other Ribosome Inactivating Proteins from the Plant Genus Trichosanthes. Fang, E. F.; Ng, T. B.; Shaw, P. C.; Wong, R. N. S. // Current Medicinal Chemistry;Oct2011, Vol. 18 Issue 28, p4410 

    Ribosome inactivating proteins (RIPs) are toxic RNA N-glycosidases that cleave an adenine-ribose glycosidic bond at position adenine4324 with the conserved ricin/α-sarcin loop in the eukaryotic 28S ribosomal RNA. RIPs have captured the attention of botanists, biochemists, and drug...

  • Refined NMR structure of α-sarcin by 15N–1H residual dipolar couplings. García-Mayoral, Mâ Flor; Pantoja-Uceda, David; Santoro, Jorge; Martínez del Pozo, Álvaro; Gavilanes, José; Rico, Manuel; Bruix, Marta // European Biophysics Journal;Nov2005, Vol. 34 Issue 8, p1057 

    15N–1H residual dipolar couplings (RDC) have been used as additional restraints to refine the solution structure of the ribotoxin α-sarcin. The RDC values were obtained by partial alignment of α-sarcin in the binary mixture of n-dodecyl hexa(ethylene glycol)/hexanol. A total of 131...

  • New Trends in Reading Instruction. Bebell, Mildred Hoyt // Educational Leadership;Dec1963, Vol. 21 Issue 3, p206 

    The article reviews the book "New Trends in Reading Instruction," by Shelley Umans.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics