Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral stones: A prospective randomized study

KC, Hari Bahadur; Shrestha, Anil; Acharya, Ganesh Bhakta; Basnet, Robin Bahadur; Shah, Arvind Kumar; Shrestha, Parash Mani
September 2016
Investigative & Clinical Urology;Sep2016, Vol. 57 Issue 5, p351
Academic Journal
Purpose: This study aimed to compare the safety and efficacy of tamsulosin and tadalafil as medical expulsive therapy for distal ureteral stones. Materials and Methods: This prospective randomized study was conducted at the Department of Urology of Bir Hospital over a period of 12 months in patients with distal ureteral stones sized 5 to 10 mm. Patients were randomly divided into 2 groups: group A received tamsulosin 0.4 mg and group B received tadalafil 10 mg at bedtime for 2 weeks. Stone expulsion rate, number of ureteric colic episodes and pain score, analgesic requirements, and adverse drug effects were noted in both groups. Statistical analyses were performed by using Student t-test and chi-square test. Results: Altogether 85 patients, 41 in group A and 44 in group B, were enrolled in the study. The patients' average age was 31.72±12.63 years, and the male-to-female ratio was 1.5:1. Demographic profiles, stone size, and baseline investigations were comparable between the 2 groups. The stone expulsion rate was significantly higher in the tadalafil group than in the tamsulosin group (84.1% vs. 61.0%, p=0.017). Although the occurrence of side effects was higher with tadalafil, this difference was not significant (p=0.099). There were no serious adverse effects. Conclusions: Tadalafil has a significantly higher stone expulsion rate than tamsulosin when used as a medical expulsive therapy for distal ureteral stones sized 5-10 mm. Both drugs are safe, effective, and well tolerated with minor side effects.


Related Articles

  • Comparative study of intrathecal hyperbaric versus isobaric ropivacaine: A randomized control trial. Gupta, Rajni; Bogra, Jaishri; Kumar Singh, Prithvi; Saxena, Sulekha; Chandra, Girish; Kumar Kushwaha, Jitendra // Saudi Journal of Anaesthesia;Jul-Sep2013, Vol. 7 Issue 3, p249 

    Background: Hyperbaric ropivacaine produce more reliable sensory and motor block, with faster onset, better quality of muscles relaxation than isobaric ropivacaine. So, this study was designed to compare the efficacy of hyperbaric ropivacaine with isobaric ropivacaine in patients undergoing...

  • Tadalafil.  // Reactions Weekly;2/25/2012, Issue 1390, p38 

    The article describes the cases of two men who developed facial flushing and mild chest discomfort during treatment with tadalafil for erectile dysfunction and lower urinary tract symptoms.

  • Microlaparoscopy Versus Conventional Laparoscopy in Transperitoneal Pyeloplasty. Benson, Aaron D.; Juliano, Trisha M.; Viprakasit, Davis P.; Herrell, S. Duke // Journal of Endourology;Dec2014, Vol. 28 Issue 12, p1404 

    Background and Purpose: Laparoscopic pyeloplasty has emerged as the gold standard for repair of ureteropelvic junction obstruction. Microlaparoscopic (MLP, <3 mm) instrumentation has improved markedly and can now be used for suturing and complex dissection needed during laparoscopic pyeloplasty....

  • Treatment Effectiveness and Side Effects: A Model of Physician Learning. Tat Chan; Narasimhan, Chakravarthi; Ying Xie // Management Science;Jun2013, Vol. 59 Issue 6, p1309 

    In this paper we study how treatment effectiveness and side effects impact the prescription decision of a risk-averse physician, and how detailing and patient feedback help reduce the physician's uncertainty in these two attributes in the erectile dysfunction category. To separately identify the...

  • Tadalafil.  // Reactions Weekly;10/13/2012, Issue 1423, p46 

    The article describes the case of a 57-year-old man who developed retinal toxicity while undergoing tadalafil therapy.

  • Tadalafil.  // Reactions Weekly;1/11/2014, Issue 1483, p91 

    The article presents a case report on the adverse reaction of tadalafil to a 52-year-old man developed a subcortical infarction after receiving the treatment.

  • Pravastatin/tadalafil interaction.  // Reactions Weekly;Sep2014, Vol. 1519 Issue 1, p134 

    The article presents a case study of a 59-year-old man diagnosed with bilateral knee and intermittent left elbow pain after administering tadalafil and pravastatin.

  • Tadalafil.  // Reactions Weekly;Nov2015, Vol. 1578 Issue 1, p270 

    The article describes a case report of a 35-year-old woman who developed tachyphylaxis, reduced blood pressure and dizziness after an off-label use of tadalafil.

  • ADVERSE DRUG REACTIONS IN NEPHROLOGY WARD INPATIENT'S OF A TERTIARY CARE HOSPITAL. Joshua, Lisha; Devi, Padmini D.; Guido, Shoba // Indian Journal of Medical Sciences;Oct2007, Vol. 61 Issue 10, p562 

    BACKGROUND: Adverse drug reactions (ADRs) are important causes of hospital admissions and inpatient complications. Renal dysfunction has a role in occurrence of ADRs. AIMS: (1) To study the characteristics of ADRs among inpatients in Nephrology ward of a tertiary care hospital and (2) to...

  • Tadalafil abuse.  // Reactions Weekly;Apr2014, Vol. 1498 Issue 1, p27 

    An abstract of the article "Fixed drug eruption caused by tadalafil--case report" by M. Bjekic and colleagues is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics