NF-κB 信号通路与糖尿病肾病治疗研究进展

孙文佳; 闵伟红; 邱斌; 徐同成; 宗爱珍
June 2016
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3589
Academic Journal
Diabetic nephropathy is mainly due to abnormal glucose metabolism of diabetes, which causing glomerular sclerosis and accompanyed abnormal urinary protein content, it is a kind of the most serious and harmful chronic complications caused by diabetes. The prevention and treatment of Diabetic nephropathy remain one of the hot spots of clinical research. NF- κB signaling pathway is a highly conservative signaling pathway made up with the nuclear factor NF-κB and its receptor, immunomodulatory protein,and involve in many biological processes such as the immune response, inflammation, apoptosis, cancer and so on. As one of the major signaling pathways involves in diabetic nephropathy, NF-κB signaling pathway can be activated to further expand diabetic nephropathy inflammation. Therefore, this article do a review on the relationship between NF- κB activation and DN inflammation, and study the NF-κB anti-inflammatory strategy, to provide theoretical basic and reliable scientific data for the prevention and treatment of diabetic nephropathy diseases.


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