夏妍; 金茜; 李兴库; 王冬; 杜博; 张淑云
June 2016
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3569
Academic Journal
Objective: To study the correlation between the EB virus(Epstein-barr virus, EBV)DNA levels in peripheral blood mononuclear cell(PBMC) of the children with EBV infection and disease spectrum and learn more about the situation of EBV infected children and the epidemiological characteristics in Heilongjiang province. Methods: Cases WEre collected in the pediatric department of internal medicine in the second affiliated hospital of Harbin medical university from June 2015 to February 2016, corresponding clinical datas also collected. The results were analyzed using the chi-square test and rank test. Results: Fluorescence quantitative PCR analysis revealed EBV DNA was detected in 43.1%(329/762)children patients. Among the children with EBV-DNA positive there is no statistical differences of the gender(P=0.182); Difference of the positive rate of EBV-DNA of the children with different ages was statistically significant(P = 0.000), the preschool group is highest and the infant group is lowest, but there is no statistical difference(P=0.337)with the trend; The largest proportion of main disease spectrum was respiratory system disease,it up to 40 cases(42.6%); IM had the highest levels of EBV-DNA, up to 1.522e+004(6.55e+001-4.602e+006), and were statistically significantly with other groups(P=0.000), but there is no statistical difference between those groups. There is a statistical difference between the levels of EBV-DNA and disease spectrum as well(p=0.000), And each kind of these diseases in the same levels of EBV-DNA with more than 10% cases were distributed in the range from(1.00-9.99)e+001 to(1.00-9.99)e+006, the highest distribute range of IM mainly from the(1.00-9.99)e+004 to(1.00-9.99)e+006, others were mainly distributed in the range from(1.00-9.99)e+001 to(1.00-9.99)e+005. Conclusion: Our study revealed that there is a higher level of EBV infection rate of the children in Heilongjiang province, and there is a closely relationship between the EBV DNA level and the disease spectrum.


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