TITLE

中西医结合治疗消化性溃疡并H.pylori感染的效果分析

AUTHOR(S)
牟少农; 王成; 雷成阳; 张婉丽; 王宁
PUB. DATE
June 2016
SOURCE
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3544
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To study the change of serum Omentin-1 level and effect of integrated traditional Chinese and Western medicine on peptic ulcer and h.pylori infection treated first failure. Methods: 82 cases of patients with peptic ulcer who were treated with amoxicillin, omeprazole, azithromycin combined with Qingyou oral solution in our hospital from September 2011 to September 2015 were selected as objects, and 20 cases of healthy people were selected as control group. Using ELISA method to detect the plasma levels of Omentin-1, the relationship between plasma levels of Omentin-1 and nitric oxide(NO), interleukin-2(IL-2), endothelin-1(ET-1), tumor necrosis factor alpha(TNF-α) were analyzed. The change of plasma levels of Omentin-1, the efficacy and safety of integrated traditional Chinese and Western medicine were observed. Results: After traditional Chinese and western medicine treatment, h. pylori eradication rate was 88.6%, 34 cases recovered, 22 cases effective, 33 cases valid, 3 cases ineffective, the healing rate was 68.29%(56/82), and the effective rate was 96.34%(79/82); theplasma level of Omentin-1in observation group was(18.15 ± 3.96) ng/mL, significantly lower than the control group(23.12 ± 6.03) ng /mL(P<0.05); compared with control group, the NO, IL-2 level of observation group was obviously lower(P< 0.05), ET-1, TNF-α and IL-6 level wasincreased significantly(P<0.05); compared with before treatment, after combined Chinese and western medicine treatment, NO, IL-2 level was significantly decreased(P< 0.05), and the ET-1, TNF-α and IL-6level was increased significantly(P< 0.05); the Omentin-1 level was significantly positively correlated with IL-2, NO(r = 0.412, P< 0.05 and r = 0.382, P< 0.05), and negatively correlated with IL-6 and TNF-α(r = 0.246, P< 0.05 and r = 0.258, P< 0.05). Conclusions: The integrated traditional Chinese and Western medicine can increase the plasma levels of Omentin-1 in patients with peptic ulcer and h.pylori infection, effectively improve the ulcer healing rate and H.pylori eradication rate, inhibit the secretion of inflammatory cytokines,enhance endogenous NO protection and the body's immune function.
ACCESSION #
118031482

 

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