TITLE

miRNA-192在骨肉瘤临床样本中的表达及与各临床要素之间关系的相关研究

AUTHOR(S)
白马恒; 马琼; 韩康; 刘增亮; 邢永军
PUB. DATE
June 2016
SOURCE
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3504
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To explore and describe the relationship of miRNA-192 function and clinicopathological features in human osteosarcoma and analyze the relationship between miRNA-192 and mortality, which support some theoretical basis for osteosarcoma treatment and element experience for further research. Methods: Real-time quantitative PCR analysis were used in 50 clinical osteosarcoma samples which were followed up. Then the relationship of miRNA-192 function and clinicopathological features(like sex,age) in human osteosarcoma were explored. Results: We found that there were statistically significant relationships between miRNA-192 expression and some clinicopathological features of osteosarcoma, including age(P = 0.028), clinical stage(P = 0.007), distant metastasis(P = 0.013) and patient mortality(P=0.001). Conclusion: In clinical specimens, miRNA-192 expression levels were correlated with some clinicopathological features of osteosarcoma, including age, clinical stage, distant metastasis and patient mortality, which provided the theoretical basis for the next study especially the biological therapy of miRNA-192 in the osteosarcoma.
ACCESSION #
118031471

 

Related Articles

  • Terminal loop-mediated control of microRNA biogenesis. Choudhury, Nila Roy; Michlewsk, Gracjan // Biochemical Society Transactions;Aug2012, Vol. 40 Issue 4, p789 

    Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate...

  • Current View of microRNA Processing. Shuai Jiang; Wei Yan // Signal Transduction Insights;2016, Issue 5, p9 

    Small evolutionarily conserved noncoding RNAs, microRNAs (miRNAs), regulate gene expression either by translational repression or by mRNA degradation in mammals. miRNAs play functional roles in diverse physiological and pathological processes. miRNA processing is accurately regulated through...

  • A 5'-uridine amplifies miRNA/miRNA asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Seitz, Hervé; Tushir, Jogender S.; Zamore, Phillip D. // Silence;2011, Vol. 2 Issue 1, p1 

    Background: MicroRNA (miRNA) are diverse in sequence and have a single known sequence bias: they tend to start with uridine (U). Results: Our analyses of fly, worm and mouse miRNA sequence data reveal that the 5'-U is recognized after miRNA production. Only one of the two strands can be...

  • MicroRNAs As Onco-miRs, Drivers of Cancer. Hede, Karyn // JNCI: Journal of the National Cancer Institute;Sep2010, Vol. 102 Issue 17, p1306 

    The article focuses on various studies which examined the role of microRNA (miRNA) in cancer formation and treatment. Several studies, the author notes, have showed the link between miRNA and invasive cancers. Some of such studies inserted a gene encoding onco-miRNA into transgenic mice and...

  • MicroRNA Expression Profiles of Stem Cells. Tolchin, Elizabeth // Genomics & Proteomics;Jul/Aug2005, Vol. 5 Issue 6, p11 

    Reports on the use of a preliminary version of the TaqMan MicroRNA (miRNA) Assays from Applied Biosystems to determine the miRNA expression profiles of mouse stem cells. Classification of embryonic stem cells according to miRNA expression profiles.

  • Behind the scenes. Ahmad, Sharon // Nature Reviews Genetics;Apr2006, Vol. 7 Issue 4, p1 

    Focuses on two papers on the discovery of additional biological functions and regulatory mechanisms of microRNA (miRNA). Role of miRNA miR-430 in the maternal to zygotic transition in embryogenesis in zebrafish; Impact of miRNA in mammalian cells on the decay of messenger RNA.

  • microRNA and skeletal muscle function: novel potential roles in exercise, diseases, and aging. McCarthy, John J.; Kunihiro Sakuma // Frontiers in Physiology;Jul2014, Vol. 5, p1 

    An introduction is presented in which the author discusses various reports within the issue on topics including the role of microRNA (miRNA) in skeletal muscles, changes in miRNA expression after exercise, and the regulation of muscle-specific miRNA.

  • RNA world: RNA stories on a mythical scale. Skipper, Magdalena // Nature Reviews Genetics;Sep2004, Vol. 5 Issue 9, p638 

    Focuses on the involvement of Argonaute proteins in some small interfering RNA (siRNA) and microRNA (miRNA) pathways. Requirement of miRNA maturation; Difference between siRNA and miRNA pathways; Function of the RNA-silencing complex.

  • Developmental biology: Tiny brakes for a growing heart. Bruneau, Benoit G. // Nature;7/14/2005, Vol. 436 Issue 7048, p181 

    Discusses the role of microribonucleic acids (miRNA) in regulating the crucial balance between growth and specialization of cardiac cells. Characteristics of miRNA; Expression pattern of the miR-1 gene; Response of miRNA to developmental cues; Expression of the Hand2 cardiac transcription factor...

  • miRNASNP: a database of miRNA related SNPs and their effects on miRNA function. Jing Gong; Yin Tong; Hong-Mei Zhang; An-Yuan Guo // BMC Bioinformatics;2012, Vol. 13 Issue Suppl 18, p1 

    An abstract of the research paper "miRNASNP: A database of miRNA related SNPs and their effects on miRNA function," by Yin Tong and colleagues is presented.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics