TITLE

异基因造血干细胞移植治疗儿童白血病87 例临床分析

AUTHOR(S)
裴夫瑜; 李七; 许文峰; 吴学东; 何岳林; 李春富; 冯晓勤
PUB. DATE
June 2016
SOURCE
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3485
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To evaluate the effect of allogeneic hematopoietic stem cell transplantation(Allo-HSCT) for children with leukemia and investigate its related influence factors. Methods: The clinical data of 87 patients with leukemia underwent HSCT at a median age of 8 years from February 2006 to December 2013 in our centerwere retrospectively analyzed, these patients were divided into BCR/ABL+ ALL, BCR/ABL- ALL, AML and CML groups according to Leukemia types. Results: The estimated 5-year overall survival(OS) was 59.7 % in total. Single factor analysis showed leukemia types(P=0.023), imatinib(P=0.008), a GVHD(P=0.001), status before transplantation(P=0.025), stem cell source(P=0.003) had significant impact on the overall survival. Multivariate analysis showed stem cell source(P=0.046), status before transplantation(P=0.048) and the transplant types(P=0.023) had significant impact on OS significantly while age, sex and leukemia types had no obvious impact OS. Conclusions: The leukemia types, imatinib, a GVHD, status before transplantation, stem cell source and transplant type were key influence factors of Allo-HSCT for pediatric leukemia.
ACCESSION #
118031466

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics