CD1a、CD209 及 MHCII在新生儿指皮组织中的表达及意义

张洁; 徐长福; 莫立平; 孙颖; 韩水平; 赵文宝
June 2016
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3452
Academic Journal
Objective: To investigate the form, number, and distribution of dendritic cells in the finger tissues of.neonates.Methods: Five autopsy samples of ring finger tissues of neonates were stained with the method of immunohistochemistry(stained with CD1 a, CD209 and MHC I) which were than observed by light microscope. Results: The positive cells in neonates were colored with brown and were different in sizes and shapes and their processes were different in numbers at scattering or focus band distribution. The expression ratio of CD1a+cells in neonates is( 23±11.9)%, which are mostly distributed in epidermal pinning processes adventitia and dermic connective tissues; the expression ratio of CD209+cells is(30±7.7)%,which are mostly distributed in dermis, like the branching of vessels and nerves、adventitia and capsule tissues of pacinian corpuscles; the expression ratio of MHCⅡ+cells is(8±1.9)%,,which are mostly distributed in adventitia and the surrounding loose connective tissue. Conclusion: In steady state, there are many kinds of DCs differentiation and envelopment in in the finger tissues of neonates(mostly immature DCs), which constitute an important part of the skin immune microenvironment.


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