TITLE

CD1a、CD209 及 MHCII在新生儿指皮组织中的表达及意义

AUTHOR(S)
张洁; 徐长福; 莫立平; 孙颖; 韩水平; 赵文宝
PUB. DATE
June 2016
SOURCE
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3452
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To investigate the form, number, and distribution of dendritic cells in the finger tissues of.neonates.Methods: Five autopsy samples of ring finger tissues of neonates were stained with the method of immunohistochemistry(stained with CD1 a, CD209 and MHC I) which were than observed by light microscope. Results: The positive cells in neonates were colored with brown and were different in sizes and shapes and their processes were different in numbers at scattering or focus band distribution. The expression ratio of CD1a+cells in neonates is( 23±11.9)%, which are mostly distributed in epidermal pinning processes adventitia and dermic connective tissues; the expression ratio of CD209+cells is(30±7.7)%,which are mostly distributed in dermis, like the branching of vessels and nerves、adventitia and capsule tissues of pacinian corpuscles; the expression ratio of MHCⅡ+cells is(8±1.9)%,,which are mostly distributed in adventitia and the surrounding loose connective tissue. Conclusion: In steady state, there are many kinds of DCs differentiation and envelopment in in the finger tissues of neonates(mostly immature DCs), which constitute an important part of the skin immune microenvironment.
ACCESSION #
118031458

 

Related Articles

  • The intracellular localization and oligomerization of chicken invariant chain with major histocompatibility complex class II subunits. H. Ye; Xu, F. Z.; Yu, W. Y. // Poultry Science;Aug2009, Vol. 88 Issue 8, p1594 

    Invariant chain (Ii) binds to MHC class II (MHCII) to assemble a nonamer in the endoplasmic reticulum. Major histocompatibility complex class II associated Ii peptide (CLIP) that occupies the peptide binding groove of MHCII prevents MHCII molecules from loading with endogenous antigens. We used...

  • Regulation of MHC class II-peptide complex expression by ubiquitination. Kyung-Jin Cho; Roche, Paul A. // Frontiers in Immunology;Nov2013, Vol. 4, p1 

    MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4+ T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has...

  • Isolation of the Promoters of Atlantic Salmon MHCII Genes. Syed, Mohasian; Vestrheim, Olav; Mikkelsen, Birthe; Lundin, Maria // Marine Biotechnology;May2003, Vol. 5 Issue 3, p253 

    Reports on the isolation of the promoters of Atlantic salmon major histocompatibility complex class II (MHCII). Construction of an Atlantic salmon promote finder kit; Functionality of the isolated salmon MHCII promoters.

  • Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming. Graham, Daniel B.; Osborne, Douglas G.; Piotrowski, Joshua T.; Gomez, Timothy S.; Gmyrek, Grzegorz B.; Akilesh, Holly M.; Dani, Adish; Billadeau, Daniel D.; Swat, Wojciech // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    Immature dendritic cells (DCs) maintain a highly dynamic pool of recycling MHCII that promotes sampling of environmental antigens for presentation to T helper cells. However, the molecular basis of MHCII recycling and the cellular machinery that orchestrates MHCII trafficking are incompletely...

  • Taking the easy way out? Schuldt, Alison // Nature Cell Biology;Sep2002, Vol. 4 Issue 9, pE213 

    Examines how the major histocompatibility complex class-II (MHC-II) molecules escape the lysosomes and move to the cell surface. Role of MHC-II in dendritic cell maturation; Use of the internal reflection microscopy to test whether tubules actually mediate transport to the cell surface.

  • HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Guce, Abigail I; Mortimer, Sarah E; Yoon, Taejin; Painter, Corrie A; Jiang, Wei; Mellins, Elizabeth D; Stern, Lawrence J // Nature Structural & Molecular Biology;Jan2013, Vol. 20 Issue 1, p90 

    Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA-DM chaperones peptide-free MHCII, protecting it against inactivation, and catalyzes peptide exchange on loaded MHCII....

  • CIITA and the MHCII Enhanceosome in the Regulation of MHCII Expression. S. Landmann; J. Waldburger; K. Masternak; A. Muhlethaler-Mottet; W. Reith // Current Genomics;May2003, Vol. 4 Issue 4, p343 

    Major Histocompatibility Complex class II (MHCII) molecules direct the development, activation and homeostasis of CD4+ T cells. Given these key functions it is not surprising that the absence of MHCII expression results in a severe primary immunodeficiency disease called MHCII deficiency or the...

  • Exposing the specific roles of the invariant chain isoforms in shaping the MHC class II peptidome. Fortin, Jean-Simon; Cloutier, Maryse; Thibodeau, Jacques // Frontiers in Immunology;Nov2013, Vol. 4, p1 

    The peptide repertoire (peptidome) associated with MHC class II molecules (MHCIIs) is influenced by the polymorphic nature of the peptide binding groove but also by cell-intrinsic factors. The invariant chain (Ii) chaperones MHCIIs, affecting their folding and trafficking. Recent discoveries...

  • The invariant chain p35 isoform promotes formation of nonameric complexes with MHC II molecules. Cloutier, Maryse; Gauthier, Catherine; Fortin, Jean‐Simon; Thibodeau, Jacques // Immunology & Cell Biology;Jul2014, Vol. 92 Issue 6, p553 

    Four different isoforms of the human invariant chain (Ii) have been described (p33, p35, p41 and p43). These heterotrimerize in the endoplasmic reticulum (ER) before associating with MHC class II molecules (MHCIIs). However, the final stoichiometry of the Ii/MHCII complex remains debated. This...

  • Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Wen, Fei; Sethi, Dhruv K.; Wucherpfennig, Kai W.; Zhao, Huimin // PEDS: Protein Engineering, Design & Selection;Sep2011, Vol. 24 Issue 9, p701 

    Reliable and robust systems for engineering functional major histocompatibility complex class II (MHCII) proteins have proved elusive. Availability of such systems would enable the engineering of peptide-MHCII (pMHCII) complexes for therapeutic and diagnostic applications. In this paper, we have...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics