宫剑英; 苏胜; 康杨; 张毅; 唐先玲; 刘平
June 2016
Progress in Modern Biomedicine;Jun2016, Vol. 16 Issue 18, p3413
Academic Journal
Objective: To study the effect of tea polyphenols on high glucose induced-human lens epithelial cells(HLECs)apoptosis. Methods: High glucose-induced HLECs model was established, different concentrations of tea polyphenols were intervened,cells viability were assayed by MTT colorimetric, cells morphology were investigated by electron microscope, cell ultrastructural changes were detected by transmission electron microscopy, expression levels of apoptosis related proteins were tested by western blotting.Results: High glucose inhibited the activity of HLECs, after the intervention of the glucose cells activity decreased to 42.65% ±4.12%,the difference has statistical significance compared with negative control group(P<0.01). After treatment with different concentrations of polyphenols, HLECs activity were increased to 55.33% ±4.15%, 72.90% ±3.36% and 76.00% ±3.79%, the difference has statistical significance compared with oxidative damage group(P<0.01); high glucose changed HLECs morphology and growth station, while cell morphology of HLECs treated with tea polyphenols intervened in high glucose conditions were better maintained; high glucose induced HLECs apoptotic response, caused apoptosis-related protein expression levels change, tea polyphenols inhibited the levels of Bax elevated and Bcl-2 declined. Conclusion: Tea polyphenols can inhibit HLECs apoptosis induced by high glucose which have prevention effect in diabetic cataract.


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