TITLE

Antiretroviral Drug Resistance Testing: Potential Use following Nosocomial Exposure to HIV

AUTHOR(S)
Worthington, Michael
PUB. DATE
December 2003
SOURCE
Clinical Infectious Diseases;12/15/2003, Vol. 37 Issue 12, p1722
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The excellent summary of the 2003 recommendations of the International AIDS society, the U.S. panel on antiretroviral drug testing in adults did not mention the potential utility of resistance testing in guiding postexposure prophylaxis (PEP) following high-risk needlestick injury in health care workers. Although there are no data from randomized controlled trials of PEP in this setting, a retrospective case-control study found an 81% reduction in the risk of HIV infection with postexposure treatment of health care workers with zidovudine. Data from clinical trials of prophylaxis against perinatal HIV transmission and from animal studies also support the effectiveness of PEP.
ACCESSION #
11770385

 

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