Progressive Reversion of Human Immunodeficiency Virus Type 1 Resistance Mutations In Vivo after Transmission of a Multiply Drug-Resistant Virus

Gandhi, Rajesh; Wurcel, Alysse; Rosenberg, Eric; Johnston, Mary; Hellmann, Nicholson; Bates, Michael; Hirsch, Martin; Walker, Bruce
December 2003
Clinical Infectious Diseases;12/15/2003, Vol. 37 Issue 12, p1693
Academic Journal
Discusses how the evolution and transmission of multiply drug-resistant human immunodeficiency virus type 1 may limit therapeutic options as global treatment expand. Need for a study to stabilize mutants in the absence of drug selection pressure; Consideration of a longitudinal analysis of plasma virus from a person who acquired HIV-1 which contained multiple reverse transcriptase and protease mutations; Reversions of a second RT mutation and 3 PR mutations which were associated with an increase in viral RC.


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