Progressive Reversion of Human Immunodeficiency Virus Type 1 Resistance Mutations In Vivo after Transmission of a Multiply Drug-Resistant Virus

Gandhi, Rajesh; Wurcel, Alysse; Rosenberg, Eric; Johnston, Mary; Hellmann, Nicholson; Bates, Michael; Hirsch, Martin; Walker, Bruce
December 2003
Clinical Infectious Diseases;12/15/2003, Vol. 37 Issue 12, p1693
Academic Journal
Discusses how the evolution and transmission of multiply drug-resistant human immunodeficiency virus type 1 may limit therapeutic options as global treatment expand. Need for a study to stabilize mutants in the absence of drug selection pressure; Consideration of a longitudinal analysis of plasma virus from a person who acquired HIV-1 which contained multiple reverse transcriptase and protease mutations; Reversions of a second RT mutation and 3 PR mutations which were associated with an increase in viral RC.


Related Articles

  • nonprogressor:. Huber, Jeffrey T.; Gillaspy, Mary L. // Encyclopedic Dictionary of AIDS-Related Terminology;2000, p163 

    A definition of the term nonprogressor, which refers to a person who tests positive for HIV antibodies but who remains healthy and does not progress to AIDS, is presented.

  • Autoreactive antibody neutralized HIV-1 infection in patient with lupus.  // Infectious Disease News;Apr2014, Vol. 27 Issue 4, p22 

    The article discusses a study led by Mattia Bonsignori, published in the April 1, 2014 issue of "The Journal of Clinical Investigation," on a broadly HIV-1 neutralizing antibody's association with a controlled viral load and plasma HIV-1 neutralization.

  • Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients. Seclén, Eduardo; González, María del Mar; Lapaz, Mariana; Rodríguez, Carmen; Del Romero, Jorge; Aguilera, Antonio; De Mendoza, Carmen; Soriano, Vincent; Poveda, Eva // Journal of Antimicrobial Chemotherapy (JAC);Dec2010, Vol. 65 Issue 12, p2502 

    Objectives Evaluation of the prevalence of V3 mutational patterns associated with maraviroc resistance in R5-using variants. Methods V3 sequences were obtained from 809 plasma specimens collected from maraviroc-naive HIV-1-infected individuals on regular follow-up at Hospital Carlos III....

  • Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5. Armand-Ugón, Mercedes; Moncunill, Gemma; Gonzalez, Emmanuel; Mena, MariaPau; Ballana, Ester; Clotet, Bonaventura; Esté, José A. // Journal of Antimicrobial Chemotherapy (JAC);Mar2010, Vol. 65 Issue 3, p417 

    Objectives: Identification of CCR5 as an antiretroviral target led to the development of several CCR5 antagonists in clinical trials and the approval of maraviroc. Evaluating the mechanism of drug resistance to CCR5 agents may have implications in the clinical development of this class of...

  • Drug Users' Self-Reported False-Positive HIV Status. Ross, Michael W.; Laxley, Wendy; Wodak, Alex; Buzolic, Adrian; Monheit, Benny; Stowe, Aaron; McCusker, Jane; Stoddard, Anne M. // American Journal of Public Health;Sep93, Vol. 83 Issue 9, p1349 

    Two letters to the editor are presented in response to the article "The Validity of Self-Reported HIV Antibody Test results," by J. McCusker, A. M. Stoddard and E. McCarthy in a 1992 issue and response by the authors to a letter by Michael W. Ross and colleagues.

  • HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 AND TYPE 2 ANTIBODIES. Schnell, Zoanne Burgess; Van Leeuwen, Anne M.; Kranpitz, Todd R. // Davis's Comprehensive Handbook of Laboratory & Diagnostic Tests ;Jan2003, p599 

    Presents a comprehensive guide to laboratory and diagnostic tests for HIV type 1 and 2 antibodies. Specimen collection; Description of the purpose of the study and insight into how and why the test results can affect health; Use of the test in terms of assessment, evaluation and assisting in the...

  • HIV antibody detection in oral fluids.  // Bulletin of the World Health Organization;1993, Vol. 71 Issue 5, p641 

    The article reports on a proposal concerning the use of oral fluids as an alternative to blood for detecting antibodies to human immunodeficiency virus (HIV). Findings of several studies indicate the adequacy of using oral fluids, such as saliva, for detecting HIV antibodies. However, a number...

  • Low incidence of syphilis among factory workers in Ethiopia: effect of an intervention based on education and counselling. T. Sahlu // Sexually Transmitted Infections;Apr2002, Vol. 78 Issue 2, p123 

    Background: The prevalence and incidence of syphilis infection were examined in a cohort study of factory workers in Ethiopia. Method: Between February 1997 and March 1999, 409 men and 348 women were enrolled and followed in the cohort study. Results: The prevalence (95% CI) of past/current...

  • Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1. Kopetzki, Erhard; Jekle, Andreas; Changhua Ji; Rao, Eileen; Zhang, Jun; Fischer, Stephan; Cammack, Nick; Sankuratri, Surya; Heilek, Gabrielle // Virology Journal;2008, Vol. 5, Special section p1 

    We describe a novel strategy in which two inhibitors of HIV viral entry were incorporated into a single molecule. This bifunctional fusion inhibitor consists of an antibody blocking the binding of HIV to its co-receptor CCR5, and a covalently linked peptide which blocks envelope mediated...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics