Pharmacogenetics of Gemtuzumab-Associated Hepatic Sinusoidal Occlusion Syndrome after Hematopoietic Stem Cell Transplant

Aplenc, Richard; Vachani, Anil; Han, Peggy; Glatfelter, Wendy; Sievers, Eric L.
December 2003
Acta Haematologica;Dec2003, Vol. 110 Issue 4, p207
Academic Journal
Presents a study that investigated the pharmacogenetics of Gemtuzumab-associated hepatic sinusoidal occlusion syndrome (SOS) after hematopoietic stem cell transplant (HSCT). Variable risk of SOS development in patients exposed to gemtuzumab after HSCT; Analysis of reactive oxygen species metabolizing genotypes as risk factors for hepatic SOS; Results and discussion.


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