Obesity-induced inflammatory changes in adipose tissue

Wellen, Kathryn E.; Hotamisligil, Gökhan S.
December 2003
Journal of Clinical Investigation;Dec2003, Vol. 112 Issue 12, p1785
Academic Journal
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.


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