TITLE

Radiation-induced leiomyosarcoma: does antimetabolite chemotherapy contribute? A report of three cases

AUTHOR(S)

Brockstein, Bruce; Mundi, Arno; Haraf, Daniel J.; Ferguson, Mark; Montag, Anthony

PUB. DATE

September 2003

SOURCE

Sarcoma;Sep-Dec2003, Vol. 7 Issue 3/4, p167

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Purpose: Radiation therapy in low and high doses is known to be associated with the occurrence of late secondary sarcomas. The addition of chemotherapy has not been clearly demonstrated as a contributing factor. We describe three patients with radiation-associated leiomyosarcoma who had also received antimetabolite chemotherapy. Methods: Three cases of leiomyosarcoma occurring 9-27 years after radiation and antimetabolite chemotherapy are presented, along with histopathological details. A Medline search was used to assess prior reports of leiomyosarcoma after radiation. Results : These three cases appear to be the first reported in which leiomyosarcoma followed therapy with radiation and antimetabolites. Discussion: With the increasing use of antimetabolite therapy combined with radiation, there is the potential for more occurrences of leiomyosarcoma or other post-treatment sarcomas.

ACCESSION #

11714987

Tags: SARCOMA;  RADIATION carcinogenesis;  ANTIMETABOLITES;  CANCER

 

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