TITLE

Inflammatory bowel disease: Crohn's disease and the success of NODern genetics

AUTHOR(S)
Newman, Bill; Siminovitch, Katherine
PUB. DATE
December 2003
SOURCE
Clinical & Investigative Medicine;Dec2003, Vol. 26 Issue 6, p303
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are multifactorial in etiology, but a major causative role for genetic factors has long been recognized. Recent advances in genetic technologies have made dissection of the genes underlying common diseases possible; consequently, there is an emerging understanding of the inherited factors that predispose to IBD. In this review, we summarize current information on the genetics of IBD, emphasizing the discovery of CARD15 variants as susceptibility alleles for Crohn's disease and the impact of this discovery on patient care and in delineating pathogenesis of this complex disease.
ACCESSION #
11698514

 

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