Photothermal detection of local thermal effects during selective nanophotothermolysis

Zharov, Vladimir P.; Galitovsky, Valentin; Viegas, Mark
December 2003
Applied Physics Letters;12/15/2003, Vol. 83 Issue 24, p4897
Academic Journal
Photothermal (PT) technique was applied to the detection of laser-induced local thermal effects around absorbing nanoparticles into cells. The experiments demonstrated the capability of this technique for studying the threshold and the dynamic of thermal events around even a single particle in a broad temperature range, including monitoring of microbubble dynamic. PT technique shows promise for optimizing cancer-cell killing by incorporation of gold nanoparticles into the cells (selective “nanophotothermolysis”), as verified by electron microscopy and conventional viability tests. © 2003 American Institute of Physics.


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