Changes of Sequestered Leukocytes and Platelets by Inhalation Prostaglandin E[sub 1] in the Pulmonary Microvasculature of Rats with Monocrotaline-Induced Pulmonary Hypertension

Kato, Shiro; Kishiro, Izumi; Sugimura, Hiroyuki; Machida, Suguru; Fuse, Daisuke; Kaneko, Noboru
February 2002
Journal of Vascular Research;2002, Vol. 39 Issue 1, p83
Academic Journal
The role of leukocytes (WBCs) and platelets (PLTs) in the pulmonary circulation may be important in the development of monocrotaline (MCT)-induced pulmonary hypertension in rats. We investigated the suppressive effects of long-term prostaglandin E[sub 1] (PGE[sub 1] ) aerosol on the changes in WBCs and PLTs in the peripheral blood and the pulmonary microvasculature during the development of chronic pulmonary hypertension in MCT rats by real-time confocal scanning laser microscopy. The number of WBCs and PLTs in peripheral blood did not significantly change by inhalation of PGE[sub 1] . The number of WBCs and PLTs sequestered in the pulmonary microvasculature of rats subjected PGE[sub 1] inhalation immediately after MCT injection rats with (MCT plus PGE[sub 1] inhalation) significantly decreased from 1 to 4 weeks compared to rats not subjected to PGE[sub 1] inhalation (p < 0.01). The pulmonary systolic arterial pressure and the weight ratio of the right ventricle to the intraventricular septum plus the left ventricle (RV/IVS + LV weight ratio or RV weight ratio) in rats with MCT plus PGE[sub 1] inhalation significantly decreased compared to rats not subjected to PGE[sub 1] inhalation (p < 0.01). The levels of peripheral CD62L-positive WBCs in rats with MCT plus PGE[sub 1] inhalation significantly decreased from 1 to 2 weeks compared to rats not subjected to PGE[sub 1] inhalation, but the levels of peripheral CD18 and CD49d-positive WBCs did not significantly change. We conclude that long-term inhalation of PGE[sub 1] is a very useful therapy in chronic pulmonary hypertension, and the mechanism of suppressing pulmonary hypertension is associated with suppressive effects on sequestered WBCs, especially CD62-positive WBCs and PLTs in the pulmonary microvasculature.Copyright © 2002 S. Karger AG, Basel


Related Articles

  • Prostaglandin E1 on Infradiaphragmatic Type of Total Anomalous Pulmonary Venous Connection - a Case Report. Cirstoveanu, Catalin; Cinteza, Eliza; Marcu, Veronica; Bizubac, Mihaela; Balomir, Alina; Barascu, Ileana; Coman, Mariana; Balgradean, Mihaela // Romanian Journal of Medical Practice;2012, Vol. 7 Issue 2, p167 

    We present the case of a newborn with severe pulmonary hypertension, diagnosed with infradiaphragmatic type of total anomalous pulmonary venous connection (TAPVC). The onset was in the first 10 days of life. Diagnosis was made by echocardiography and AngioCT. The pulmonary venous collector was...

  • Suppressive Effect of Prostaglandin E[sub 1] on Pulmonary Hypertension Induced by Monocrotaline... Sakuma, F.; Miyata, M.; Kasukawa, R. // Lung;1999, Vol. 177 Issue 2, p77 

    Studies the effect of prostaglandin E[sub 1] on monocrotaline-induced pulmonary hypertension and cytokine production by macrophages during the monocrotaline induction of pulmonary hypertension. Effectiveness of administering prostaglandin E[sub 1] in the treatment of some forms of pulmonary...

  • Circulating Platelet Aggregates Indicative of in Vivo Platelet Activation in Pulmonary Hypertension. Lopes, Antonio Augusto; Maeda, Nair Yukie; Almeida, Ana; Jaeger, Rui; Ebaid, Munir; Chamone, Dalton Fischer // Angiology;Sep1993, Vol. 44 Issue 9, p701 

    The authors investigated the existence of circulating cellular aggregates in 12 patients with moderate to severe pulmonary hypertension, using scanning electron microscopy. Peripheral venous blood was collected in the presence of 11.5 mM buffered ethylenediaminetetraacetic acid, in order to...

  • Role of P-Selectin in Platelet Sequestration in Pulmonary Capillaries during Endotoxemia. Kiefmann, Rainer; Heckel, Kai; Schenkat, Sonja; Dörger, Martina; Goetz, Alwin Eduard // Journal of Vascular Research;Sep2006, Vol. 43 Issue 5, p473 

    Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia. The aims of the present study were to localize platelet sequestration in the pulmonary microcirculation and to investigate the role of...

  • 5th Scientific Workshops and Debates of the Pulmonary Vascular Research Institute (PVRI) Cape Town, South Africa 7-10 February, 2012.  // Pulmonary Circulation;2011, Vol. 1 Issue 4, pS16 

    The article presents abstracts on medical topics which include the protection of high altitude against irreversible pulmonary hypertension, clinical outcome of pulmonary hypertension among admitted heart failure patients, and platelet function and morphology in idiopathic pulmonary hypertension.

  • Complement C3 Deficiency Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in Mice. Bauer, Eileen M.; Han Zheng; Comhair, Suzy; Erzurum, Serpil; Billiar, Timothy R.; Bauer, Philip M. // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Background: Evidence suggests a role of both innate and adaptive immunity in the development of pulmonary arterial hypertension. The complement system is a key sentry of the innate immune system and bridges innate and adaptive immunity. To date there are no studies addressing a role for the...

  • Foreword.  // Current Medical Literature: Pulmonary Hypertension;2012, Vol. 3 Issue 1, pIV 

    A foreword to the "Current Medical Literature: Pulmonary Hypertension" is presented.

  • Empowered Patient Online Toolkit.  // Advances in Pulmonary Hypertension;Summer2012, Vol. 11 Issue 2, p104 

    The article recommends the comprehensive Empowered Patient Toolkit for patients with pulmonary hypertension by Pulmonary Hypertension Association (PHA).

  • Survival in Patients with Primary Pulmonary Hypertension. D'Alonzo, Gilbert F.; Barst, Robyn J.; Ayres, Stephen M.; Bergofsky, Edward H.; Brundage, Bruce H.; Detre, Katherine M.; Fishman, Alfred P.; Goldring, Roberta M.; Groves, Berton M.; Kernis, Janet T.; Levy, Paul S.; Pietra, Giuseppe G.; Reid, Lynne M.; Reeves, John T.; Rich, Stuart; Vreim, Carol E.; Williams, George W.; Wu, Margaret // Annals of Internal Medicine;9/1/91, Vol. 115 Issue 5, p343 

    Presents information on a study that characterized mortality in persons diagnosed with primary pulmonary hypertension and investigated factors associated with survival. Research methods; Results and discussion on the study; Conclusions.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics