TITLE

Cough frequency in children with stable asthma: correlation with lung function, exhaled nitric oxide, and sputum eosinophil count

AUTHOR(S)
Li A M; Lex C; Zacharasiewicz A; Wong E; Erin E; Hansel T; Wilson N M; Bush A
PUB. DATE
November 2003
SOURCE
Thorax;Nov2003, Vol. 58 Issue 11, p974
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND: A study was undertaken to assess the correlation between cough frequency in asthmatic children with lung function and two non-invasive markers of airway inflammation. METHODS: Thirty two children of median age 12.0 years (interquartile range (IQR) 9.5-13.4) with stable asthma were recruited. They underwent spirometric testing, exhaled nitric oxide (eNO) measurement, sputum induction for differential cell count, and ambulatory cough monitoring over 17 hours and 40 minutes. Coughing episodes were counted both as individual spikes and as clusters. RESULTS: Complete cough frequency data were available in 29 children (90%) and their median forced expiratory volume in 1 second (FEV1) and eNO were 88.5% (IQR 79.5-98) and 23.9 ppb (IQR 11.4-41.5), respectively. The median number of cough episodes was 14 (IQR 7.0-24.0) which was significantly higher than that of normal children (6.7 (IQR 4.1-10.5), p<0.001). Sputum induction was successful in 61% of the subjects; the median induced sputum eosinophil count was 0.05% (IQR 0-9.0). Cough frequency was found to have a significant positive correlation with eNO (Spearman's r =0.781, p<0.001) but not with FEV1 or sputum eosinophil count (r =-0.270, p=0.157; r =0.173, p=0.508, respectively). CONCLUSIONS: Children with stable asthma have increased cough frequency compared with normal controls and cough frequency was greater during the day than at night. Cough may be a more sensitive marker of airway inflammation than simple spirometry.
ACCESSION #
11582897

 

Related Articles

  • MECHANICAL IN-EXSUFFLATION: MORE THAN JUST AIRWAY CLEARANCE IN PEDIATRIC PATIENTS. Miske, Laura J.; Weiner, Daniel J.; Panitch, Howard B. // Current Medical Literature: Pediatrics;2004, Vol. 17 Issue 2, p29 

    Focuses on the use of mechanical in-exsufflators to facilitate airway clearance in pediatric patients with impaired cough. Methods for assisting with an effective cough maneuver; Alternative mechanical devices used for airway clearance; Benefits of mechanical in-exsufflators.

  • Long-term low-dose erythromycin in patients with unexplained chronic cough: a double-blind placebo controlled trial. Nadia Yousaf // Thorax;Dec2010, Vol. 65 Issue 12, p1107 

    AIMS: Unexplained chronic cough is a common condition with no satisfactory treatments. Previous work has suggested that cough may be linked to neutrophilic airway inflammation. This study tested the hypothesis that long-term low-dose erythromycin reduces the induced sputum neutrophil count and...

  • Non-cystic fibrosis bronchiectasis. McDonnell, M.J.; Ward, C.; Lordan, J.L.; Rutherford, R.M. // QJM: An International Journal of Medicine;Aug2013, Vol. 106 Issue 8, p709 

    Bronchiectasis is a chronic debilitating condition with considerable phenotypic diversity. A vicious cycle of infection and inflammation exists in damaged airways with patients suffering from persistent cough, purulent sputum production, recurrent chest infections and general malaise. The...

  • Inflammatory Mediators in Induced Sputum and Airway Hyperresponsiveness in Cough Variant Asthma during Long-Term Inhaled Corticosteroid Treatment. Meixuan Liu; Kaixiong Liu; Ning Zhu; Jingwen Xia; Xiaodong Chen // Mediators of Inflammation;2012, Vol. 2012, p1 

    Objective. This study aimed to investigate improvements in inflammatory mediator levels in induced sputum and airway hyperresponsiveness (AHR) in cough variant asthma (CVA) during long-terminhaled corticosteroid (ICS) treatment. Patients and Methods. Patients with CVA (N = 35) and classic asthma...

  • A case of cough, lymphocytic bronchoalveolitis and coeliac disease with improvement following a gluten free diet. Brightling, C. E.; Symon, F. A.; Birring, S. S.; Wardlaw, A. J.; Robinson, R.; Pavord, I. D. // Thorax;Jan2002, Vol. 57 Issue 1, p91 

    Chronic cough is a common reason for presentation to a respiratory clinic. In up to 20% of cases the cause remains unclear after investigations. We report one such case where ere was bronchoscopic evidence of lymphocytic airway inflammation in association with newly diagnosed coeliac disease....

  • Relation between measurement of cough severity. Chang, A.B.; Phelan, P.D.; Robertson, C.F.; Roberts, R.G.D.; Sawyer, S.M. // Archives of Disease in Childhood;Jan2003, Vol. 88 Issue 1, p57 

    Background: In asthma, measurements of airway inflammation correlate poorly with clinical markers and airway hyperresponsiveness. While the relation between determinants of asthma severity is known, that for cough is unknown. We hypothesised that cough sensitivity changes relate to changes in...

  • Cough suppressants for children.  // British Medical Journal;8/28/1976, Vol. 2 Issue 6034, p493 

    Focuses on the treatment of cough in children in Great Britain. Determination of the cause of the disease; Prescription of antibiotics to the patient; Frequency of prescribing cough suppressant in children.

  • Consider psychogenic cough in children.  // Pulse;7/4/2012, Vol. 72 Issue 24, p12 

    The article offers information on the psychogenic cough in children, which could be the cause of chronic cough that does not wake children at night.

  • Epidemiological Features of Pertussis in Hospitalized Patients in Canada, 1991-1997: Report of... Halperin, Scott A.; Wang, Elaine E. L.; Law, Barbara; Mills, Elaine; Morris, Rob; Dery, Pierre; Lebel, Marc; MacDonald, Noni; Jadavji, Taj; Vaudry, Wendy; Scheifele, David; Delage, Gilles; Duclos, Philippe // Clinical Infectious Diseases;6/1/1999, Vol. 28 Issue 6, p1238 

    Assesses the morbidity associated with the continued high levels of pertussis among Canadian children less than two years of age who were admitted to the Immunization Monitoring Program-Active centers. Complications caused by pertussis; Influence of pertussis on morbidity and mortality rates in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics