TITLE

Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD

AUTHOR(S)
Culpitt S V; Rogers D F; Fenwick P S; Shah P; De Matos C; Russell R E K; Barnes P J; Donnelly L E
PUB. DATE
November 2003
SOURCE
Thorax;Nov2003, Vol. 58 Issue 11, p942
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND: The pathophysiology of chronic obstructive pulmonary disease (COPD) features pulmonary inflammation with a predominant alveolar macrophage involvement. Bronchoalveolar macrophages from patients with COPD release increased amounts of inflammatory cytokines in vitro, an effect that is not inhibited by the glucocorticosteroid dexamethasone. Resveratrol (3,5,4'-trihydroxystilbene) is a component of red wine extract that has anti-inflammatory and antioxidant properties. A study was undertaken to determine whether or not resveratrol would inhibit cytokine release in vitro by alveolar macrophages from patients with COPD. METHODS: Alveolar macrophages were isolated from bronchoalveolar lavage (BAL) fluid from cigarette smokers and from patients with COPD (n=15 per group). The macrophages were stimulated with either interleukin (IL)-1beta or cigarette smoke media (CSM) to release IL-8 and granulocyte macrophage-colony stimulating factor (GM-CSF). The effect of resveratrol was examined on both basal and stimulated cytokine release. RESULTS: Resveratrol inhibited basal release of IL-8 in smokers and patients with COPD by 94% and 88% respectively, and inhibited GM-CSF release by 79% and 76% respectively. Resveratrol also inhibited stimulated cytokine release. Resveratrol reduced IL-1beta stimulated IL-8 and GM-CSF release in both smokers and COPD patients to below basal levels. In addition, resveratrol inhibited CSM stimulated IL-8 release by 61% and 51% respectively in smokers and COPD patients, and inhibited GM-CSF release by 49% for both subject groups. CONCLUSIONS: Resveratrol inhibits inflammatory cytokine release from alveolar macrophages in COPD. Resveratrol or similar compounds may be effective pharmacotherapy for macrophage pathophysiology in COPD.
ACCESSION #
11582889

 

Related Articles

  • Increased Coexpression of Eotaxin and Interleukin 5 in Bullous Pemphigoid. Shrikhande, M.; Hunziker, T.; Braathen, L. R.; Pichler, W. J.; Dahinden, C. A.; Yawalkar, N. // Acta Dermato-Venereologica;Jul/Aug2000, Vol. 80 Issue 4, p277 

    While the presence of eosinophils in the skin lesions of bullous pemphigoid is well documented, the chemotactic factors responsible for eosinophil recruitment into the tissue still remain to be defined. In this study, eotaxin and interleukin-5 (IL-5) concentrations were determined in the blister...

  • IL-4, TGF-β, NF-κB and MPO Levels in Patients With Treatment Resistant Schizophrenia. KARTALCI, Şükrü; GÖNENİR ERBAY, Lale; PORGALI ZAYMAN, Esra; OTLU, Önder; BAY KARABULUT, Aysun; KARTALCI, Gülşen // Turkish Journal of Psychiatry;2016, Vol. 27 Issue 3, p1 

    Objective: Schizophrenia is a chronic psychotic disorder in which genetics and environmental factors such as infection and the corresponding immune response play a role in the etiopathogenesis. The aim of this study was to compare some immune factors such as nuclear factor-κB (NF-κB)...

  • Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma. Jun-ichi Akahira; Ryo Konno; Kiyoshi Ito; Kunihiro Okamura; Nobuo Yaegashi // International Journal of Clinical Oncology;Feb2004, Vol. 9 Issue 1, p42 

    Background Interleukin-18 (IL-18), a cytokine produced by macrophages, is capable of inducing T-lymphocyte synthesis of interferon-G (IFN-G). In this study, for the first time, the serum concentration of IL-18 and its significance as a prognostic indicator was evaluated in patients with...

  • Roles of the mesangium in glomerular function. Schlöndorff, Detlef // Kidney International;Jun1996, Vol. 49 Issue 6, p1583 

    Among the multiple functions of the mesangial cell in glomerular physiology and pathophysiology, those of structural support of the capillary network, of participation in filtration regulation and in glomerular injury have attracted considerable interest. These roles are supported by studies...

  • TNF in Pathophysiology: Biosynthetic Regulation. Beutler, Bruce // Journal of Investigative Dermatology;Dec90 Supplement, Vol. 95, p81S 

    Though the inflammatory response is a primitive one, most inflammatory reactions would not occur without the intercession of highly specialized cells. Inflammation is one aspect of immunity, and as such, is governed by lymphocytes and macrophages. Two broad categories of study have emerged in...

  • The role of inflammation and interleukin-1 in acute cerebrovascular disease. Galea, James; Brough, David // Journal of Inflammation Research; 

    Acute cerebrovascular disease can affect people at all stages of life, from neonates to the elderly, with devastating consequences. It is responsible for up to 10% of deaths worldwide, is a major cause of disability, and represents an area of real unmet clinical need. Acute cerebrovascular...

  • IL-1RII mRNA Expression is Significantly Decreased in the Endometrial Tissue of Women with Endometriosis.  // Fertility Weekly;4/1/2002, p4 

    Defective IL-1R gene expression during the early stages of endometriosis may contribute to the etiology of the disease. Interleukin 1 (IL-1) is a major pro inflammatory cytokine that is believed to play a central role in the pathophysiology of endometriosis. The IL-1 receptor type II (IL- 1RII)...

  • Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites. Hamid, Yasmin H.; Urhammer, Søren A.; Jensen, Dorit P.; Glümer, Charlotte; Borch-Johnsen, Knut; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf // Diabetes;Dec2004, Vol. 53 Issue 12, p3342 

    Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 α-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit...

  • Interleucina-6: ¿amiga o enemiga? Bases para comprender su utilidad como objetivo terapéutico. Ramírez, Publio Giovanni Saavedra; Duque, Gloria María Vásquez; Naranjo, Luis Alonso González // Iatreia;Jun2011, Vol. 24 Issue 2, p157 

    Cytokines are intercellular communication molecules. They exhibit a great range of actions in different systems and organic processes, notably in the mechanisms that produce the inflammatory response. Interleukin-6 is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics