Review: Depression, social isolation, and certain life events are associated with the development of coronary heart disease

November 2003
ACP Journal Club;Nov/Dec2003, Vol. 139 Issue 3, p81
Academic Journal
This article discusses whether certain psychosocial risk factors are associated with development and progression of coronary heart disease (CHD). Reviews were selected if they were published in English in peer-reviewed journals after 1979. They included prospective studies with 100 patients, and CHD outcomes included myocardial infarction, myocardial revascularization, and CHD death. 2 investigators independently assessed the quality of the selected reviews using a validated 7-point score. For reviews with a score less than 4, data were extracted on years covered, reviewers' backgrounds, Stressors examined, number of studies, outcomes, measures of association, results, confounders, features of causality, statistical and clinical significance. The evidence in support of an association was rated as good, fair and poor. When reviews included both prospective and case-control studies, only the data pertaining to prospective studies were included.


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