Review: Drugs do not improve symptoms in urinary urge incontinence and may have side effects: COMMENTARY

Pannill 3d, Fitzhugh C.
November 2003
ACP Journal Club;Nov/Dec2003, Vol. 139 Issue 3, p76
Academic Journal
Despite decades of using anti-cholinergic drugs for urinary incontinence (UI), few well-designed, controlled trials have supported the efficacy of these drugs. Researchers G. Haeusler and colleagues have identified double-blind trials that were published up to October 2000. Only 8 of 36 studies enrolled have more than 100 patients, and outcomes were mostly based on subjective reports by patients rather than urodynamic results. Trials of non-pharmacologic therapies that incorporated independent drug-placebo comparison arms that might have been included were not. None of the trials included elderly patients with dementia, a group with a high frequency of UI in whom delirium associated with anti-cholinergic agents is a major adverse effect.


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