Chemoprophylaxis with aspirin (81 mg daily) reduced the incidence of colorectal adenomas in persons at risk

November 2003
ACP Journal Club;Nov/Dec2003, Vol. 139 Issue 3, p72
Academic Journal
This article discusses whether chemoprophylaxis with aspirin is more effective than placebo for reducing the incidence of colorectal adenomas in persons at risk of histologically documented adenomas. 1121 patients, who were histologically confirmed that their colorectal adenoma was removed in less than 3 months before recruitment. Exclusion criteria included a history of a familial colorectal cancer syndrome, invasive colorectal cancer, and malabsorption syndromes. Follow-up was 97%. In less than a year, colorectal adenoma was detected in fewer patients who received aspirin than in those who received placebo.


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