Estrogen plus progestin increased risk for breast cancer in postmenopausal women: COMMENTARY

Thacker, Holly L.
November 2003
ACP Journal Club;Nov/Dec2003, Vol. 139 Issue 3, p61
Academic Journal
The study by researchers R.T. Chlebowski and colleagues gives detailed information regarding breast cancer risk in late postmenopausal women using estrogen-plus-progestin hormone therapy (HT). No increased risk for breast cancer death was reported in HT users, and the diagnosis of metastatic breast cancer was observed in 1% of HT users compared with 2% of placebo users. A study has also found that current HT therapy, particularly estrogen plus progestin, was associated with increased risk for breast cancer. However, past use was not associated with such risk. It is becoming clear that current estrogen-plus-progestin HT carries greater breast cancer risk than estrogen alone.


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