Atorvastatin reduced coronary and stroke events in patients with hypertension and without dyslipidemia: COMMENTARY

Simon, Joel A.
November 2003
ACP Journal Club;Nov/Dec2003, Vol. 139 Issue 3, p57
Academic Journal
Except for the Antihypertensivc and Lipid-Lowering Heart Attack Trial (ALLHAT), which was non-blinded and suffered from the frequent use of statins among participants who were allocated to placebo, Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA) has joined other primary and secondary coronary heart disease (CHD) prevention studies showing that lowering low-density lipoprotein cholesterol with statins prevents CHD events among persons at higher CHD risk. Primary CHD-prevention statins trials, including ASCOT-LLA, when taken together have additionally shown a trend toward lower all-cause mortality. Although benefit correlates with the magnitude of cholesterol lowering, statins have important effects on inflammatory markers, plaque stabilization, nitric oxide production, and thrombosis that probably add to their effectiveness.


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