TITLE

Epstein-Barr Virus DNA Loads in Adult Human Immunodeficiency Virus Type 1--Infected Patients Receiving Highly Active Antiretroviral Therapy

AUTHOR(S)
Ling, Paul D.; Vilchez, Regis A.; Keitel, Wendy A.; Poston, David G.; Rong Sheng Peng, David G.; White, Zoe S.; Visnegarwala, Fehmida; Lewis, Dorothy E.; Butel, Janet S.
PUB. DATE
November 2003
SOURCE
Clinical Infectious Diseases;11/1/2003, Vol. 37 Issue 9, p1244
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Patients with human immunodeficiency virus type 1 (HIV-1) infection are at high risk of developing Epstein­Barr virus (EBV)-associated lymphoma. However, little is known of the EBV DNA loads in patients receiving highly active antiretroviral therapy (HAART). Using a real-time quantitative polymerase chain reaction assay, we demonstrated that significantly more HIV-1-infected patients receiving HAART that HIV-1-uninfected volunteers had detectable EBV DNA in blood (57[81%] of 70 vs. 11[16%] of 68 patients; P = .001) and saliva (55[79%] of 68 vs. 37[54%] of 68 patients; P = .002). The mean EBV loads in blood and saliva samples were also higher in HIV-1-infected patients that in HIV-1-uninfected volunteers (P = .001). The frequency of EBV detection in blood was associated with lower CD4[sup+] cell counts (P = .03) among HIV-1-infected group. Additional studies are needed to determine whether EBV-specific CD4[sup+] and CD8[sup+] cells play a role in the pathogenesis of EBV in HIV-1-infected patients receiving HAART.
ACCESSION #
11491503

 

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