Neisseria meningitidis Carriage during an Outbreak of Serogroup C Disease

David M. Patrick, Margarida; Champagne, Sylvie; Goh, Swee-Han; Arsenault, Gillian; Thomas, Eva; Shaw, Carol; Rahim, Tazim; Taha, Fatma; Bigham, Mark; Dubenko, Valerie; Skowronski, Danuta; Bruham, Robert C.
November 2003
Clinical Infectious Diseases;11/1/2003, Vol. 37 Issue 9, p1183
Academic Journal
During 2001, an outbreak of serogroup C meningococcal disease led to immunization of individuals aged 13–29 years in Abbotsford, British Columbia, Canada. This study addresses the distribution of Neisseria meningitides carriage in this population and the implications of that distribution for the targeting of the immunization campaign. Pharyngeal swabs were obtained at immunization from 2004 people. Colonies were identified and serogrouped using standard agglutination methods and by PCR. Isolates were characterized using pulsed-field gel electrophoresis (PFGE). The prevalence of N. meningitidis carriage was 153 carriers per 2004 subjects (7.6%; 95% confidence interval, 6.5%–8.9%). Only 6 (4%) of the isolates from these carriers were found to be serogroup C by agglutination of PCR testing, and all of these were from individuals within the age group targeted for immunization. Only 1 of these 6 isolates was found to be identical to the outbreak strain by PFGE. The observation that a virulent strain is not circulating widely suggests the possibility of low background immunity in the population at risk and emphasizes the importance of vaccination in controlling epidemic group C meningococcal disease.


Related Articles

  • Polio in Tajikistan: A Reminder of the Risk of Importations to Polio-free Regions.  // Immunization Newsletter;2010, Vol. 32 Issue 4, p1 

    The article reports on the implementation of various immunization campaings using the polio type 1 vaccine to prevent the polio outbreak in Tajikistan caused by poliovirus type 1 which started in April 2010.

  • Flu guard. Mathai, Dr Gita // Telegraph (Calcutta, India);3/2/2015, p9 

    The article reports on the ways for the prevention of epidemics in India including the need to follow the hygiene techniques, the availability of immunisation against flu, and the significance of wearing a face mask.

  • Yellow fever, Liberia.  // Weekly Epidemiological Record;3/12/2004, Vol. 79 Issue 11, p101 

    Reports on the outbreak of yellow fever in five counties of Liberia. Confirmation through laboratory reports for two of the counties; Commencement of the mass immunization campaign; Support from the world bodies and NGOs for the implementation of the immunization campaign.

  • Immunisation the birth. Jarvis, Sarah // Update;10/2/2003, Vol. 67 Issue 7, p393 

    In this article the author discusses the role of immunization in preventing epidemics. This article gives details of the origin of vaccination and misconceptions regarding it in the public. It gives information on both passive and active forms of immunisation. It discusses factors on which the...

  • Hope is not a strategy. Martin, Jeannett // Practice Nursing;Sep2012, Vol. 23 Issue 9, p429 

    The author discusses the rise in the number of cases of whooping cough or pertussis in England and Wales in 2012, with 2466 cases already reported in 2012. The Health Protection Agency (HPA) is working with the Department of Health's Joint Committee on Vaccination and Immunization (JCVI) to find...

  • Vaccination against infectious diseases: What is promising? Doerr, Hans; Berger, Annemarie // Medical Microbiology & Immunology;Dec2014, Vol. 203 Issue 6, p365 

    Vaccination has proven to be one of the best weapons protecting the mankind against infectious diseases. Along with the huge progress in microbiology, numerous highly efficacious and safe vaccines have been produced by conventional technology (cultivation), by the use of molecular biology...

  • Measles eradication--lofty goal or major distraction? Koehlmoos, Tracey // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;3/12/2011, Vol. 342 Issue 7797, p582 

    A personal narrative is presented which explores the author's experience of participating in studies on measles eradication.

  • Biochemical Characterization of Anopheles gambiae SRPN6, a Malaria Parasite Invasion Marker in Mosquitoes. Chunju An; Yasuaki Hiromasa; Xin Zhang; Lovell, Scott; Zolkiewski, Michal; Tomich, John M.; Michel, Kristin // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasis, thrombolysis and innate immune responses. Additionally, non-inhibitory serpins serve functions as chaperones, hormone transporters, or antiangiogenic factors. In the African malaria mosquito,...

  • PEDIATRIC BRIEFS.  // Clinical Pediatrics;Feb1967, Vol. 6 Issue 2, Following p126 

    The recommendations of the United States Public Health Service Advisory Committee on Immunization Practices on influenza vaccines for civilian use for the 1966 to 1967 period are presented. Influenza vaccine has shown protective value when the viruses in the vaccine have been antigenically...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics