TITLE

A Fatal Case of West Nile Virus Infection in a Bone Marrow Transplant Recipient

AUTHOR(S)
Hiatt, Bradley; DesJardin, Lucy; Carter, Thomas; Gingrich, Roger; Thompson, Curt; de Magalhaes-Silverman, Margarida
PUB. DATE
November 2003
SOURCE
Clinical Infectious Diseases;11/1/2003, Vol. 37 Issue 9, p129
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
West Nile virus (WNV) can cause severe, potentially fatal neurological illness, which include encephalitis, meningitis, Guillain­Barré syndrome, and anterior myelitis. Because of the short viremic phase, WNV infection is most commonly diagnosed by detection of immunoglobulin M antibody to WNV in serum or cerebrospinal fluid (CSF). We describe a patient with T cell lymphoma who had undergone a T cell-depleted bone marrow transplantation and developed fatal WNV infection. The results of serological tests of blood samples and of CSF tests were negative. Diagnosis was made postmortem by a positive result of reverse-transcriptase polymerase chain reaction (ABI 7700; TaqMan) for WNV in stored CSF and serum samples.
ACCESSION #
11491490

 

Related Articles

  • Patients with West Nile virus meningitis or encephalitis, but not acute flaccid paralysis, had favorable outcomes.  // ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p78 

    This article presents a study, to determine the long-term outcome for patients with neurologic manifestations of West Nile virus (WNV) infection. 16 patients, with confirmed WNV infection were detected. WNV-specific antibodies were detected in acute-phase serum or cerebrospinal fluid samples by...

  • Persistent Neuroinvasive West Nile Virus Infection in an Immunocompromised Patient. Penn, Robert G.; Guarner, Jeannette; Sejvar, James J.; Hartman, Herbert; McComb, Rodney D.; Nevins, Diana L.; Bhatnagar, Julu; Zaki, Sherif R. // Clinical Infectious Diseases;3/1/2006, Vol. 42 Issue 5, p680 

    A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were...

  • West Nile Virus Infection in Humans and Horses, Cuba. Pupo, Maritza; Guzmán, Maria Guadalupe; Fernández, Roberto; Llop, Alina; Dickinson, Félix Orlando; Pérez, Daniel; Cruz, Raúl; González, Tayri; Estévez, Gonzalo; González, Hiram; Santos, Paulino; Kourí, Gustavo; Andonova, Maya; Lindsay, Robbin; Artsob, Harvey; Drebot, Michael // Emerging Infectious Diseases;Jun2006, Vol. 12 Issue 6, p1022 

    A surveillance system to detect West Nile virus (WNV) was established in Cuba in 2002. WNV infection was confirmed by serologic assays in 4 asymptomatic horses and 3 humans with encephalitis in 2003 and 2004. These results are the first reported evidence of WNV activity in Cuba.

  • Five-Year Surveillance of West Nile and Eastern Equine Encephalitis Viruses in Southeastern Virginia. Loftin, Karin C.; Diallo, Alpha A.; Herbert, Marcia W.; Phaltankar, Priyarshadan G.; Yuan, Christine; Grefe, Norman; Flemming, Agnes; Foley, Kirby; Williams, Jason; Fisher, Sandra L.; Elberfeld, Michael; Constantine, Juan; Burcham, Mitchell; Stallings, Valerie; Xia, Dongxiang // Journal of Environmental Health;May2006, Vol. 68 Issue 9, p33 

    To investigate the occurrence of West Nile virus (WNV) and Eastern equine encephalitis virus (EEE) in southeastern Virginia, the Bureau of Laboratories at the Norfolk Department of Public Health (NDPH) analyzed mosquito pools and the sera of sentinel chickens from the southeastern Virginia area...

  • © PRIMARY ANTIBODY RESPONSES OF HERONS TO EXPERIMENTAL INFECTION WITH MURRAY VALLEY ENCEPHALITIS AND KUNJIN VIRUSES. Boyle, David B.; Marshall, Ian D.; Dickerman, Robert W. // Australian Journal of Experimental Biology & Medical Science;Dec1983, Vol. 61 Issue 6, p665 

    Examines the antibody responses of rufous night herons and little egrets following infection with Murray Valley encephalitis and Kunjin viruses. Detection of hemugglutinin-inhibiting antibodies; Observation that neutralizing antibody development paralleled that of H1 antibodies; Possibility of...

  • Patients with West Nile virus meningitis or encephalitis, but not acute flaccid paralysis, had favorable outcomes: COMMENTARY. Schattner, Ami // ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p78 

    Since its appearance in New York in August 1999, human infection with West Nile Virus (WNV) has spread over much of the United States and adjacent Canada. As of January 2004, 8977 human cases of WNV infection, have been reported to the U.S. Centers for Disease Control and Prevention. The vast...

  • Persistence of Virus-Reactive Serum Immunoglobulin M Antibody in Confirmed West Nile Virus Encephalitis Cases. Roehrig, John T.; Nash, Denis; Maldin, Beth; Labowitz, Anne; Martin, Denise A.; Lanciotti, Robert S.; Campbell, Grant L. // Emerging Infectious Diseases;Mar2003, Vol. 9 Issue 3, p376 

    Presents a study which focused on the persistence of virus-reactive serum immunoglobulin M antibody in confirmed West Nile virus encephalitis cases. Methods; Results; Discussion.

  • Presencia del virus del oeste del Nilo en el noreste de México. Fernández-Salas, Ildefonso; Garza-Rodríguez, María de Lourdes; Beaty, Barry J.; Jiménez, Javier Ramos; Rivas-Estilla, Ana María // Salud Pública de México;may/jun2007, Vol. 49 Issue 3, p210 

    Objective. To investigate the presence of WNV in birds, horses and humans in northeast Mexico. Material and Methods. Serum samples from 33 birds, 24 horses and 237 humans were screened by ELISA for Anti-WNV antibodies. Human serum samples were also screened for WNV RNA using an RT-PCR assay....

  • West Nile Virus Neutralization by Plasma Immunoglobulin. John Jr., Joseph F. // Infectious Disease Alert;Sep2007, Vol. 26 Issue 12, p136 

    THERE IS NO PROVEN THERAPY FOR INFECTION DUE TO the mosquito-borne flavivirus West Nile Virus, introduced to a fully susceptible U.S. population in 1999. There have been more than 2 million cases since its introduction and the spectrum of disease has expanded to include diverse neurological...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics