A Fatal Case of West Nile Virus Infection in a Bone Marrow Transplant Recipient

Hiatt, Bradley; DesJardin, Lucy; Carter, Thomas; Gingrich, Roger; Thompson, Curt; de Magalhaes-Silverman, Margarida
November 2003
Clinical Infectious Diseases;11/1/2003, Vol. 37 Issue 9, p129
Academic Journal
West Nile virus (WNV) can cause severe, potentially fatal neurological illness, which include encephalitis, meningitis, Guillain­Barré syndrome, and anterior myelitis. Because of the short viremic phase, WNV infection is most commonly diagnosed by detection of immunoglobulin M antibody to WNV in serum or cerebrospinal fluid (CSF). We describe a patient with T cell lymphoma who had undergone a T cell-depleted bone marrow transplantation and developed fatal WNV infection. The results of serological tests of blood samples and of CSF tests were negative. Diagnosis was made postmortem by a positive result of reverse-transcriptase polymerase chain reaction (ABI 7700; TaqMan) for WNV in stored CSF and serum samples.


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