TITLE

Improvement of Systemic Human Immunodeficiency Virus--Related Non-Hodgkin Lymphoma Outcome in the Era of Highly Active Antiretroviral Therapy

AUTHOR(S)
Vaccher, Emanuela; Spina, Michele; Talamini, Renato; Zanetti, Martina; Di Gennaro, Giampiero; Nasti, Guglielmo; Tavio, Marcello; Bernardi, Daniele; Simonelli, Cecilia; Tirelli, Umberto
PUB. DATE
December 2003
SOURCE
Clinical Infectious Diseases;12/1/2003, Vol. 37 Issue 11, p1556
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To assess the impact of highly active antiretroviral therapy (HAART) on the outcome of systemic human immunodeficiency virus­related non-Hodgkin lymphoma (HIV-NHL), we retrospectively analyzed 235 patients in whom HIV-NHL was diagnosed from April 1988 through December 1999. A multivariate Cox proportional hazards model was used to estimate prognostic factors for overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS). Complete remission occurred in 49% of patients, and the 3-year rates of OS, PFS, and DFS were 19%, 49%, and 73%, respectively. The greatest risk for shortened OS, PFS, and DFS was associated with no HAART use (compared with long-term HAART use); hazard ratios were 17.42 (95% confidence interval [CI], 17.42–40.25), 9.11 (95% CI, 3.71–22.32), and 8.54 (95% CI, 1.19–61.11), respectively. Our study suggests that the long-term use of HAART may favorably change the outcome for patients with systemic HIV-NHL.
ACCESSION #
11472241

 

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