Improvement of Systemic Human Immunodeficiency Virus--Related Non-Hodgkin Lymphoma Outcome in the Era of Highly Active Antiretroviral Therapy

Vaccher, Emanuela; Spina, Michele; Talamini, Renato; Zanetti, Martina; Di Gennaro, Giampiero; Nasti, Guglielmo; Tavio, Marcello; Bernardi, Daniele; Simonelli, Cecilia; Tirelli, Umberto
December 2003
Clinical Infectious Diseases;12/1/2003, Vol. 37 Issue 11, p1556
Academic Journal
To assess the impact of highly active antiretroviral therapy (HAART) on the outcome of systemic human immunodeficiency virus­related non-Hodgkin lymphoma (HIV-NHL), we retrospectively analyzed 235 patients in whom HIV-NHL was diagnosed from April 1988 through December 1999. A multivariate Cox proportional hazards model was used to estimate prognostic factors for overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS). Complete remission occurred in 49% of patients, and the 3-year rates of OS, PFS, and DFS were 19%, 49%, and 73%, respectively. The greatest risk for shortened OS, PFS, and DFS was associated with no HAART use (compared with long-term HAART use); hazard ratios were 17.42 (95% confidence interval [CI], 17.42–40.25), 9.11 (95% CI, 3.71–22.32), and 8.54 (95% CI, 1.19–61.11), respectively. Our study suggests that the long-term use of HAART may favorably change the outcome for patients with systemic HIV-NHL.


Related Articles

  • Centroblastic-centrocytic lymphoma arising at the site of previous herpes zoster eruption. Drago, Francesco; Rampini, Paolo; Lugani, Cesare; Rebora, Alfredo // Acta Dermato-Venereologica;4/20/98, Vol. 78 Issue 1, p74 

    Describes a case of centroblastic-centrocytic lymphoma arising at the site of previous herpes zoster eruption. Case background; Occurrence of new skin disorder at the site of another one that is already healed and unrelated; Low-grade malignant B cell lymphoma.

  • Prognostic significance of t(14;18) and bcl-2 gene... Martinka, Magda; Comeau, Terry // Clinical & Investigative Medicine;Dec97, Vol. 20 Issue 6, p364 

    Evaluates whether there is an association between the presence of t(14;18) and bcl-2 gene expression in patients with follicular small cleaved cell lymphoma (FSCCL) and diffuse large cell lymphoma (DLCL). Materials and methods used; Clinical stage at diagnosis and t(14;18); Response to...

  • Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement. Pienkowska-Grela, Barbara; Rymkiewicz, Grzegorz; Grygalewicz, Beata; Woroniecka, Renata; Krawczyk, Paulina; Czyz-Domanska, Katarzyna; Walewski, Jan // Medical Oncology;Dec2011, Vol. 28 Issue 4, p1589 

    Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma characterized by specific morphological and immunophenotypic features. The basic genetic feature of BL is the rearrangement of MYC gene, visible as t(8;14)(q24;q32) translocation or its variant. However, some lymphomas with...

  • RECRUITMENT COMPLETED IN OFATUMUMAB NHL PIVOTAL STUDY.  // Worldwide Biotech;Nov2008, Vol. 20 Issue 11, p3 

    The article reports on the completion of the recruitment of patients in the pivotal Phase III study of ofatumumab HuMax-CD20 in rituximab refractory follicular non-Hodgkin's lymphoma (NHL) by Genmab A/S. The study has recruited 81 patients receiving treatment at the 1000 milligram (mg) dose...

  • The Current Management of Mantle Cell Lymphoma. Rule, Simon // Current Medical Literature: Leukemia & Lymphoma;2003, Vol. 11 Issue 2, p23 

    Focuses on the treatment of mantle cell lymphoma (MCL). Prognostic factors identified for MCL; Drugs for MCL; Survival rate of MCL patients who underwent Hyper-CVAD regimen.

  • Foreword. Sweetenham, John // Current Medical Literature: Leukemia & Lymphoma;2006, Vol. 14 Issue 1, preceding p1 

    States that the papers cited in the journal "Current Medical Literature--Leukemia & Lymphoma" is a valuable resource for those people interested in hematological malignancy. Description of the papers published in the journal; Comment on articles included in the journal; Importance of the journal.

  • Lymphoma Associated with Gastrointestinal Adenocarcinoma. Thurnherr, N.; Sherlock, P.; Winawer, S. J.; Katz, S. // American Journal of Gastroenterology;Jan1974, Vol. 61 Issue 1, p28 

    Investigates cases of lymphoma with gastrointestinal adenocarcinoma. Background on the patients; Result of the x-rays of the gastrointestinal tract; Treatment of the patients;

  • Scoring relevancy of features based on combinatorial analysis of Lasso with application to lymphoma diagnosis. Zare, Habil; Haffari, Gholamreza; Gupta, Arvind; Brinkman, Ryan R. // BMC Genomics;2013, Vol. 14 Issue Suppl 1, p1 

    One challenge in applying bioinformatic tools to clinical or biological data is high number of features that might be provided to the learning algorithm without any prior knowledge on which ones should be used. In such applications, the number of features can drastically exceed the number of...

  • CITATIONS AND CLINICIANS NOTES: HODGKIN S DISEASE.  // Current Medical Literature: Leukemia & Lymphoma;2004, Vol. 12 Issue 3, p61 

    Presents an abstract of the study "Familial Aggregation of Hodgkin Lymphoma and Related Tumors," by L. R. Goldin, R. M. Pfeiffer, G. Gridley et al.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics