TITLE

Decreased Serum Opsonic Activity against Streptococcus pneumoniae in Human Immunodeficiency Virus--Infected Ugandan Adults

AUTHOR(S)
Takahashi, Hidehiko; Oishi, Kazunori; Yoshimine, Hiroyuhi; Kumatori, Atsushi; Moji, Kazuhiko; Watanabe, Kiwao; Nalwoga, Hawa; Buguruka Tugume, Sitefano; Kebba, Anthony; Mugerwa, Roy; Mugyenyi, Peter; Nagatake, Tsuyoshi
PUB. DATE
December 2003
SOURCE
Clinical Infectious Diseases;12/1/2003, Vol. 37 Issue 11, p1534
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community-acquired pneumonia and 58 asymptomatic Ugandan adults with or without human immunodeficiency virus type 1 (HIV-1) infection. The levels of serum IgG to CPS were significantly higher in HIV-1–infected subjects than in HIV-uninfected subjects. Serum samples from HIV-1–infected subjects that had lower IgG titers demonstrated higher opsonic activity against type 3 (titers of 7) and type 9 (titers of 7–11) pneumococcal strains. Plasma HIV-1 load also correlated inversely with serum opsonic activity against these strains, and peripheral blood CD4[sup+] lymphocyte numbers also tended to correlate with serum opsonic activity in asymp-tomatic HIV-1—infected adults. Our findings suggest that the opsonic activity of type-specific IgG is impaired in the serum of HIV-1—infected African adults, which may expose them to a serious risk of invasive pneumococcal infections.
ACCESSION #
11472169

 

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