Invasive Pneumococcal Disease in Scotland, 1999--2001: Use of Record Linkage to Explore Associations between Patients and Disease in Relation to Future Vaccination Policy

Kyaw, Moe H.; Christie, Peter; Clarke, Stuart C.; Mooney, John D.; Ahmed, Syed; Jones, Ian G.; Campbell, Harry
November 2003
Clinical Infectious Diseases;11/15/2003, Vol. 37 Issue 10, p1283
Academic Journal
A record linkage study was done to provide comprehensive data on the epidemiologic characteristics of invasive pneumococcal disease (IPD) in Scotland. The overall incidence of IPD was 11 cases/10[sup5] persons and 21 cases/10[sup5] persons <1 year of age, 51 cases/10[sup5] persons 1 year of age, 45 cases/10[sup5] elderly persons (age ≥65 years), 176–483 cases/10[sup5] persons with chronic medical conditions, and 562–2031 cases/10[sup5] persons with severe immunosuppression. The case-fatality rate was 11% among elderly persons and ranged from 3% to 13% among persons with underlying medical conditions. The most common pneumococcal serogroups associated with IPD were 14, 9, 6, 19, 23, 8, and 4. Serogroups included in the 23-valent polysaccharide vaccine caused the majority of cases of IPD. The proportion of IPD due to the 7­, 9­, and 11­valent conjugate vaccine serogroups was lower among older people and persons with underlying medical conditions.


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