TITLE

The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics

AUTHOR(S)
Lynch, Maureen; Shieh, Wun-Ju; Tatti, Kathleen; Gentsch, Jon R.; Ferebee-Harris, Tara; Jiang, Baoming; Guarner, Jeannette; Bresee, Joseph S.; Greenwald, Margaret; Cullen, Steve; Davies, H. D.; Trevenen, Cynthia; Zaki, Sherif R.; Glass, Roger I.
PUB. DATE
November 2003
SOURCE
Clinical Infectious Diseases;11/15/2003, Vol. 37 Issue 10, p1327
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Rotavirus, the most common cause of severe, dehydrating gastroenteritis among children worldwide, annually causes ∼500,000 deaths among children aged <5 years. The primary site of rotavirus infection is the small intestine. Pathologic investigations of patients who died of rotavirus infection are limited to data from a few reported autopsies, and dehydration with electrolyte imbalance is believed to be the major cause of death. Several recent reports suggest that children who died during a rotavirus illness were viremic before death, because rotavirus was detected at several extraintestinal sites. We report 3 rotavirus-associated deaths among children, 2 of whom had evidence of rotavirus genome in extraintestinal tissues detected by use of novel molecular diagnostic methods. The part played by rotavirus in fatal cases is unclear and requires additional investigation of diarrhea-associated deaths, because a better understanding might alter the approach to treatment and the need for antiviral therapy.
ACCESSION #
11470970

 

Related Articles

  • Outbreak of rotavirus gastroenteritis with high mortality, Nicaragua, 2005. Amador, Juan José; Vicari, Andrea; Turcios-Ruiz, Reina M.; Melendez D., Ana Christian; Malek, Mark; Michel, Fabiana; Aldighieri, Sylvain; Kerin, Tara; Bresee, Joseph S.; Glass, Roger I.; Andrus, Jon K. // Pan American Journal of Public Health;Apr2008, Vol. 23 Issue 4, p277 

    Objectives. We investigated a nationwide outbreak of severe rotavirus gastroenteritis in Nicaragua in children under 5 years old, leading to many consultations, hospitalizations, and deaths. We questioned whether a vaccine might have prevented these illnesses and deaths, sought to identify risk...

  • Projected Impact of the New Rotavirus Vaccination Program on Hospitalizations for Gastroenteritis and Rotavirus Disease among US Children <5 Years of Age during 2006-2015. Curns, Aaron T.; Coffin, Fanny; Glasser, John W.; Glass, Roger I.; Parashar, Umesh D. // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS49 

    Background. Rotavirus causes approximately one-third to one-half (55,000-70,000 hospitalizations per year) of hospitalizations for acute gastroenteritis (AGE) among US children ,5 years of age. We forecasted the potential reduction in the number of hospitalizations for rotavirus disease and AGE...

  • Genetic and Antigenic Diversity of Human Rotaviruses: Potential Impact on Vaccination Programs. Kirkwood, Carl D. // Journal of Infectious Diseases;9/1/2010 Supplement, Vol. 202, pS43 

    The successful development and implementation of rotavirus vaccines will have a significant impact on rotavirus-induced gastroenteritis in children worldwide. However, this introduction will increase the immune pressure against wild-type rotavirus strains circulating in the community, altering...

  • Molecular Characterization of Rotavirus Strains Circulating among Children with Acute Gastroenteritis in Madagascar during 2004-2005. Adiku, T. K.; Dove, W.; Grosjean, P.; Combe, P.; Nakagomi, T.; Nakagomi, O.; Hart, C. A.; Cunliffe, N. A. // Journal of Infectious Diseases;9/1/2010 Supplement, Vol. 202, pS175 

    A survey was undertaken of the etiology of acute gastroenteritis in children <16 years of age in Antananarivo, Madagascar, from May 2004 through May 2005. With use of electron microscopy of fecal specimens, 104 (36%) of 285 children were found to be infected with rotavirus. Rotavirus strain...

  • Characterization of Human Rotavirus Recovered from Children ~th Acute Diarrhea in Kinshasa, Democratic Republic of Congo. Kabue, J. P.; Peenze, I.; de Beer, M.; Esona, M. D.; Lunfungula, C.; Biamungu, M.; Simba, T. R.; Tamfum, J. J. Muyembe; Steele, A. Duncan // Journal of Infectious Diseases;9/1/2010 Supplement, Vol. 202, pS193 

    Between July and October of 2003, 2004, and 2005, outbreaks of acute gastroenteritis occurred among children <5 years of age in Kinshasa, Democratic Republic of the Congo. Stool specimens (67 in 2003, 108 in 2004, and 116 in 2005) were collected and screened for rotaviruses using either latex...

  • Oral Rotavirus Vaccines: How Well Will They Work Where They Are Needed Most? Patel, Manish; Shane, Andi L.; Parashar, Umesh D.; Baoming Jiang; Gentsch, Jon R.; Glass, Roger I. // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS39 

    Rotavirus vaccines hold promise to decrease the burden of severe diarrhea in the poorest countries, where 85% of deaths due to rotavirus occur. However, the potency of live oral vaccines is lower in these challenging settings than in middle- and upper-income countries. Many hypotheses have been...

  • A prognostic score in Rotavirus gastroenteritis in children. Haliţchi1, Codruţa Iliescu; Rusu, Wanda; Temneanu, Oana; Pavel, Ana; Chirilă, Alina; Rotaru, Bogdan; Russu, Radu; Moraru, Dan // Romanian Journal of Pediatrics;2013, Vol. 62 Issue 3, p279 

    Diarrhea is a major health problem and a common cause of morbidity and mortality in children, Rotavirus being the most frequent cause of infectious diarrhea in infants and young children. Aim. Evaluation of patients diagnosted and treated at Arcadia Hospital with Rotavirus gastroenteritis...

  • Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran. Sanaei Dashti, Anahita; Ghahremani, Pedram; Hashempoor, Tayebeh; Karimi, Abdollah // Gastroenterology Research & Practice;1/10/2016, p1 

    Background. Acute gastroenteritis is one of the major sources of morbidity and mortality among young children in developed and developing countries. The aim of this study was to determine the prevalence of human adenovirus- (HAdV-) 40 and HAdV-41 in children hospitalized with gastroenteritis in...

  • Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries. Diez-Domingo, Javier; Baldo, Jose-Maria; Patrzalek, Marian; Pazdiora, Petr; Forster, Johannes; Cantarutti, Luigi; Pirçon, Jean-Yves; Soriano-Gabarró, Montse; Meyer, Nadia; Pirçon, Jean-Yves; Soriano-Gabarró, Montse; SPRIK Rotavirus Study Group // European Journal of Pediatrics;Feb2011, Vol. 170 Issue 2, p213 

    This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, Germany, Italy, Poland, Spain and the UK. Children aged <5...

  • Rotavirus Gastroenteritis in Uzbekistan: Implications for Vaccine Policy in Central Asia. Flem, Elmira T.; Musabaev, Erkin; Juraev, Rivojiddin; Kerin, Tara; Gentsch, Jon; Glass, Roger I.; Bresee, Joseph S. // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS154 

    Background. To determine the value of rotavirus vaccines in Central Asia, we conducted surveillance of rotavirus in Uzbekistan, the country with the largest birth cohort in the region. Uzbekistan is eligible for international funds to introduce new vaccines. Methods. We screened stool samples...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics