TITLE

Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection

AUTHOR(S)
Giannini, Edoardo; Botta, Federica; Borro, Paolo; Malfatti, Federica; Fumagalli, Alessandra; Testa, Emanuela; Podestà, Elena; Chiarbonello, Bruno; Polegato, Simone; Mamone, Mario; Testa, Roberto
PUB. DATE
November 2003
SOURCE
American Journal of Gastroenterology;Nov2003, Vol. 98 Issue 11, p2516
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
: ObjectivesThrombopoietin (Tpo) is an important regulator of megakaryocyte maturation and platelet production, and is mainly produced by the liver. A decrease in Tpo production is partly responsible for the thrombocytopenia observed in patients with chronic liver disease (CLD). The aim of this study was to evaluate the relationship between Tpo serum levels and liver function in patients with CLD related to hepatitis C virus (HCV) infection.: MethodsWe studied 37 patients with various degrees of HCV-related CLD. Of the patients, 17 had chronic hepatitis and 20 liver cirrhosis. Liver function was evaluated in all patients by the following hepatic blood flow dependent and independent tests that explore various hepatic metabolic functions: carbon-13 (13C)–aminopyrine breath test (13C-ABT), 13C-galactose breath test (13C-GBT), and monoethylglycinexylidide (MEGX) test. Liver function tests results were correlated with Tpo serum levels.: ResultsTpo serum levels were significantly lower in patients with liver cirrhosis (88 ± 23 pg/ml) as compared to those in patients with chronic hepatitis (128 ± 55 pg/ml, p = 0.0031). However, they did not correlate with serum albumin, bilirubin, or prothrombin activity. Tpo serum levels showed a significant positive correlation with 13C-ABT results (hourly dose at 30 min, rs= 0.489, p = 0.002; cumulative dose at 120 min, rs= 0.425, p = 0.008). Moreover, they showed a fair, positive correlation with 13C-GBT hourly dose at 30 min (rs= 0.366, p = 0.028), and a trend toward a positive correlation with the various MEGX test sampling times (MEGX15, rs= 0.314, p = 0.059; MEGX30, rs= 0.284, p = 0.088; and MEGX60, rs= 0.320, p = 0.059).: ConclusionsIn this study we have shown that a progressive decline in liver function in patients with HCV-related CLD is paralleled by a decrease in Tpo production. The different correlations observed between Tpo and the various liver function tests suggests that this finding is mainly the result of a decrease in hepatic functional mass rather than dependent on alteration in splanchnic hemodynamic.
ACCESSION #
11469051

 

Related Articles

  • A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts. Challier, C; Cocault, L; Flon, M; Pauchard, M; Porteu, F; Gisselbrecht, S; Souyri, M // Oncogene;4/13/2000, Vol. 19 Issue 16, p2033 

    Mpl is the receptor for thrombopoietin, the primary regulator of platelet production by megakaryocytes. Upon stimulation by its ligand, Mpl receptor induces proliferation and differentiation of hematopoietic cell lines of various origins. In this paper, we show that Mpl is also able to transform...

  • Total remission of severe immune thrombocytopenia after short term treatment with romiplostim. Vlachaki, Efthymia; Papageorgiou, Vaia; Klonizakis, Filippos; Spandonidou, Maria; Chisan, Sofia; Vetsiou, Evaggelia; Ioannidou, Elissavet // Hematology Reviews;2011, Vol. 3 Issue 3, p58 

    Immune thrombocytopenia (ITP) in adults is an acquired chronic immune-mediated disorder defined by isolated thrombocytopenia. In recent years, an improved understanding of the pathophysiology of ITP has been achieved and it is now accepted that the disorder is due to increased platelet...

  • High Concentrations of Thrombopoietin Activate Platelets In Vitro. Hammond, William P.; Wun, Theorode; Kaplan, Alexander; Kaplan, Svetlana; Paglieroni, Teresa; Kaushansky, Kenneth; Foster, Donald C. // Clinical & Applied Thrombosis/Hemostasis;Jul1998, Vol. 4 Issue 3, p170 

    Thrombopoietin (TPO), the ligand for the protooncogene c-mpl has been cloned and expressed from both human and murine sources. Thrombopoietin increases platelet counts when given in vivo and acts on progenitor cells to increase their proliferation and maturation into megakaryocytes. The effects...

  • Aging platelets stimulate TPO production. Kile, Benjamin T // Nature Medicine;Jan2015, Vol. 21 Issue 1, p11 

    The article focuses on a study related to production of growth factor thrombopoietin (TPO) by hepatocytes in mice, driven by platelet clearance. The study published in journal "Nature Medicine" shows increase in half life of platelet in mice by genetic deletion of Ashwell-Morell receptor (AMR)...

  • Evaluating the safety and efficacy of recombinant human thrombopoietin among severe sepsis patients with thrombocytopenia: study protocol for a randomized controlled trial. Qin Wu; Jianan Ren; Gefei Wang; Guosheng Gu; Dong Hu; Song Liu; Gunawei Li; Jun Chen; Ranran Li; Zhiwu Hong; Huajian Ren; Xiuwen Wu; Yuan Li; Min Yao; Yunzhao Zhao; Jieshou Li // Trials;2015, Vol. 16 Issue 1, p1 

    Background: Sepsis is still a major health problem that causes high mortality in all populations. Organ dysfunction including sepsis-associated thrombocytopenia is prevalent among sepsis patients, resulting in increasing mortality rates. Considering the clinical role of platelets,...

  • The molecular mechanisms that control thrombopoiesis. Kaushansky, Kenneth // Journal of Clinical Investigation;Dec2005, Vol. 115 Issue 12, p3339 

    Our understanding of thrombopoiesis - the formation of blood platelets - has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal...

  • Lonely in Paris:when one gene copy isn't enough. Shivdasani, Rarnesh A. // Journal of Clinical Investigation;Jul2004, Vol. 114 Issue 1, p17 

    Circulating platelets are continually replenished by fragmentation of terminally differentiated megakaryocytes. Processes disrupted in inherited thrombocytopenias frequently shed light on normal thrombopoietic mechanisms. An especially rare condition called Paris-Trousseau syndrome (PTS) seems...

  • Plasma thrombopoietin levels in marrow transplant patients with veno-occlusive disease of the liver. Oh, H; Tahara, T; Bouvier, M; Farrand, A; McDonald, G B // Bone Marrow Transplantation;10/1/98, Vol. 22 Issue 7, p675 

    Platelet transfusion requirements are higher among patients with veno-occlusive disease (VOD), compared to patients without VOD. One possible explanation is inadequate production of thrombopoietin (TPO), a protein synthesized in the liver. We prospectively studied 28 patients to test the...

  • Treatment with L-Valine Ameliorates Liver Fibrosis and Restores Thrombopoiesis in Rats Exposed to Carbon Tetrachloride. Nakanishi, Chikashi; Doi, Hideyuki; Katsura, Kazunori; Satomi, Susumu // Tohoku Journal of Experimental Medicine;Jun2010, Vol. 221 Issue 2, p151 

    It has been reported that treatment with branched chain amino acids (BCAAs) increases the survival rates in cirrhotic patients. In this study, we investigated the effect of L-valine, one of BCAAs, on liver fibrosis in rat. To induce liver fibrosis, male Wistar rats were injected carbon...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics