TITLE

Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus—infected patients receiving ribavirin plus interferon alfa

AUTHOR(S)
Dieterich, Douglas T.; Wasserman, Ronald; Bräu, Norbert; Hassanein, Tarek I.; Bini, Edmund J.; Bowers, Peter J.; Sulkowski, Mark S.
PUB. DATE
November 2003
SOURCE
American Journal of Gastroenterology;Nov2003, Vol. 98 Issue 11, p2491
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
: ObjectiveThe aim of this study was to determine the efficacy of epoetin alfa in alleviating anemia and minimizing ribavirin (RBV) dose reductions in patients with chronic hepatitis C virus (HCV) infection receiving combination RBV/interferon alfa (IFN) therapy.: MethodsHCV-infected patients who had Hb levels of 12 g/dl or less during the first 24 wk of combination RBV/IFN therapy (n = 64) were randomized to treatment with epoetin alfa (40,000 units) s.c. q.w. or to standard of care (SOC) for anemia management (RBV dose reduction or discontinuation, transfusions). Primary and secondary efficacy endpoints were changes in Hb level and RBV dosage, respectively, from baseline to week 16 of epoetin alfa therapy.: ResultsBased on intent-to-treat analysis, the mean changes from baseline Hb levels at week 16 were +2.8 g/dl for epoetin alfa versus +0.4 g/dl for SOC (p < 0.0001), and the mean changes in RBV dosage were −34 mg/day for epoetin alfa versus −146 mg/day (p = 0.060) for SOC. The mean Hb level at week 16 in the epoetin alfa group (13.8 g/dl) was significantly (p < 0.0001) higher than that of the SOC group (11.4 g/dl). At week 4 and subsequently, significantly more patients in the epoetin alfa group did not have RBV dosage reductions (p < 0.011). At study end, 83% of epoetin alfa–treated patients maintained RBV dosages of at least 800 mg/day, compared with 54% of patients receiving SOC (p = 0.022). Epoetin alfa was well tolerated.: ConclusionsIn anemic HCV-infected patients treated with RBV/IFN, epoetin alfa increases Hb levels and maintains RBV dosing. Based on these results, epoetin alfa seems to be promising in the treatment of HCV treatment–related anemia. Further research is warranted to determine the potential impact on outcomes, including quality of life and sustained viral response rate.
ACCESSION #
11469048

 

Related Articles

  • Ribavirin-Induced Anemia in Hepatitis C Virus Patients Undergoing Combination Therapy. Krishnan, Sheeja M.; Dixit, Narendra M. // PLoS Computational Biology;Feb2011, Vol. 7 Issue 2, p1 

    The current standard of care for hepatitis C virus (HCV) infection - combination therapy with pegylated interferon and ribavirin - elicits sustained responses in only ∼50% of the patients treated. No alternatives exist for patients who do not respond to combination therapy. Addition of...

  • Anemia in the Treatment of Hepatitis C Virus Infection. Sulkowski, Mark S. // Clinical Infectious Diseases;11/15/2003 Supplement, Vol. 37, pS315 

    Hepatitis C virus (HCV) infection is a significant worldwide health care problem. Nearly one-third of all patients infected with human immunodeficiency virus (HIV) are coinfected with HCV. Compared with HIV-monoinfected persons, coinfected individuals experience more rapid progression of...

  • Individualized Therapy for Hepatitis C Infection: Focus on the Interleukin-28B Polymorphism in Directing Therapy. Lee, Tzu-Hao; Tillmann, Hans; Patel, Keyur // Molecular Diagnosis & Therapy;Feb2014, Vol. 18 Issue 1, p25 

    Hepatitis C virus-a major global cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma-affects millions of people worldwide. Pegylated interferon (Peg-IFN) and ribavirin (RBV) had been the standard treatment for a decade until availability of the protease inhibitors in 2011....

  • Oral TJ 48 for interferon-α-2b/ ribavirin-associated anaemia.  // Reactions Weekly;3/12/2005, Issue 1042, p4 

    Discusses research being done on the ability of Oral TJ 48 therapy to reduce the anaemia associated with interferon and ribavirin combination therapy in patients with chronic hepatitis C virus infection. Reference to a study by Y. Sho, K. Fujisaki, H. Sakashita, et al., published in the...

  • Treatment of anicteric acute hepatitis C with peginterferon alpha-2a plus ribavirin. Delić, Dragan; Nešić, Zorica; Prostran, Milica; Simonović, Jasmina; Švirtlih, Neda // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Nov2005, Vol. 62 Issue 11, p865 

    Background Hepatitis C virus (HCV) infection is the most frequent cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma in the world. Acute hepatitis C is the most commonly asymptomatic liver disease with the development of chronic HCV infection in the majority of infected...

  • Management of Hepatitis C Virus-Related Arthritis. Zuckerman, E.; Yeshurun, D.; Rosner, I. // BioDrugs;2001, Vol. 15 Issue 9, p573 

    Hepatitis C virus (HCV) infection is often associated with extrahepatic manifestations among which arthropathy is common, affecting up to 20% of HCV-infected individuals. This arthropathy is to be distinguished from the more superficially prominent myalgias and fatigue. HCV-related arthritis is...

  • Optimum Duration of Treatment for Hepatitis C.  // Neurology Alert;Sep2007 Supplement, Vol. 26, p18 

    The article discusses research on optimum duration of treatment for hepatitis C. It references a study by M. L. Shiffman et al, published in the 2007 of the "New England Journal of Medicine." The standard treatment for hepatitis C called sustained viral response (SVR) is defined as an absence of...

  • Efficacy of High-Dose Interferon in Combination With Ribavirin in Patients With Chronic Hepatitis C Resistant to Interferon Alone. Min, Albert D.; Jones, Jennifer L.; Esposito, Stephen; Lebovics, Edward; Jacobson, Ira M.; Klion, Franklin M.; Goldman, Ira S.; Geders, Jane M.; Tobias, Hillel; Bodian, Carol; Bodenheimer Jr., Henry C. // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1143 

    OBJECTIVE: Interferon combined with ribavirin has efficacy in the treatment of patients with chronic hepatitis C virus (HCV) infection. However, its utility in patients who have not responded to prior interferon therapy is not clear. Furthermore, the effect of using an increased dose of...

  • Ribavirin monotherapy for hepatitis C virus-associated membranous nephropathy. Hu, S. L.; Jaber, B. L. // Clinical Nephrology;2005, Vol. 63 Issue 1, p41 

    Glomerular diseases associated with hepatitis C virus (HCV) infection are increasingly being recognized. Antiviral therapy with interferon-α (IFN-α) and ribavirin eradicate viral activity in a significant proportion of patients with chronic active hepatitis, often with amelioration of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics