TITLE

Circulating ghrelin levels in celiac patients

AUTHOR(S)
Peracchi, Maddalena; Conte, Dario; Terrani, Claudia; Pizzinelli, Simona; Gebbia, Carlotta; Cappiello, Vincenzo; Spada, Anna; Bardella, Maria Teresa
PUB. DATE
November 2003
SOURCE
American Journal of Gastroenterology;Nov2003, Vol. 98 Issue 11, p2474
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
: ObjectiveGhrelin, the gut–brain peptide, recently identified as the natural endogenous ligand for growth hormone secretagogue receptors, exerts various endocrine and nonendocrine effects, including the control of energy homeostasis and food intake, but its possible relevance in malabsorption syndromes is unknown. Therefore, the aim of this study was to evaluate circulating ghrelin levels in adults with untreated and treated celiac disease (CD) and, for comparison, in healthy subjects.: MethodsFasting serum ghrelin levels were measured in 30 consecutive patients with newly diagnosed CD, 13 celiac patients successfully treated with a gluten-free diet (GFD), and 30 healthy controls.: ResultsGhrelin levels were abnormally high in patients with active CD compared with controls (297 ± 17.6 vs 218 ± 15.2 pmol/L, p < 0.01) and correlated positively with intestinal mucosal lesion severity (rs = 0.444, p < 0.02). In the successfully GFD-treated patients, ghrelin values were normal compared with controls (233 ± 22.0 vs 218 ± 15.2 pmol/L, ns) and, moreover, correlated negatively with body mass index (r = −0.632, p = 0.02), unlike in the untreated patient group (r = −0.263, ns).: ConclusionHigh ghrelin levels characterized our series of adult patients with newly diagnosed CD and correlated significantly with the degree of severity of intestinal mucosal lesions. This is the first evidence of a relationship between ghrelin and inflammatory processes, but the mechanisms involved are still unclear. Furthermore, our findings suggest that an interplay of hormonal, metabolic, and nutritional factors could influence ghrelin secretion under pathophysiological circumstances.
ACCESSION #
11469045

 

Related Articles

  • Peptide signals regulating food intake and energy homeostasis. Blevins, James E.; Schwartz, Michael W.; Baskin, Denis G. // Canadian Journal of Physiology & Pharmacology;May2002, Vol. 80 Issue 5, p396 

    The adiposity hormone leptin has been shown to decrease food intake and body weight by acting on neuropeptide circuits in the hypothalamus. However, it is not clear how this primary hypothalamic action of leptin is translated into a change in food intake. We hypothesize that the behavioral...

  • Interactions of Gastrointestinal Peptides: Ghrelin and Its Anorexigenic Antagonists. Wisser, Anna-Sophia; Habbel, Piet; Wiedenmann, Bertram; F. Klapp, Burghard; Mönnikes, Hubert; Kobelt, Peter // International Journal of Peptides;2010, p1 

    Food intake behaviour and energy homeostasis are strongly regulated by a complex system of humoral factors and nerval structures constituting the brain-gut-axis. To date the only known peripherally produced and centrally acting peptide that stimulates food intake is ghrelin, which is mainly...

  • Peptide YY levels are decreased by fasting and elevated following caloric intake but are not regulated by leptin. Chan, J.; Stoyneva, V.; Kelesidis, T.; Raciti, P.; Mantzoros, C. // Diabetologia;Jan2006, Vol. 49 Issue 1, p169 

    Aims/hypothesis: Peptide YY (PYY) is a gut-derived hormone that has been shown to reduce short-term food intake in animals and humans. It has been proposed that deficiency of PYY contributes to obesity in humans. However, the physiology of PYY regulation by factors such as caloric restriction,...

  • Gastrointestinal regulation of food intake. Cummings, David E.; Overduin, Joost // Journal of Clinical Investigation;Jan2007, Vol. 117 Issue 1, p13 

    Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable body weight, because overall caloric ingestion and expenditure are exquisitely matched over long periods of time, through the process of energy homeostasis. The brain receives hormonal, neural, and...

  • Keeping hunger at bay. Schwartz, Michael W.; Morton, Gergory J. // Nature;8/8/2002, Vol. 418 Issue 6898, p595 

    Describes how the hormone peptide YY[sub3-36] which suppresses appetite for up to 12 hours can control food intake. Factors that trigger the onset and termination of eating; Information on the hormone peptide YY[sub3-36].

  • Guanylin family: new intestinal peptides regulating electrolyte and water homeostasis. Nakazato, Masamitsu // Journal of Gastroenterology;2001, Vol. 36 Issue 4, p219 

    The regulation of intestinal salt and water transport is critical to the maintenance of fluid volume. Control of this life-sustaining activity is mediated by the concerted actions of hormones, neurotransmitters, and locally acting factors. Guanylin and uroguanylin are novel peptides that were...

  • Central nervous system control of food intake. Schwartz, Michael W.; Woods, Stephen C. // Nature;4/6/2000, Vol. 404 Issue 6778, p661 

    Describes a model on the achievement of energy homeostasis in humans. Delineation of the roles of individual hormonal and neuropeptide signaling pathways in the control of food intake; Linking of defects in the signaling pathways for the development of obesity; Insights from laboratory studies...

  • Adiposity and the Gut - The Role of Gut Hormones. Amber, Vian; Bloom, Stephen R. // Current Nutrition & Food Science;2007, Vol. 3 Issue 1, p75 

    The WHO has declared that obesity is one of the top five risk conditions in the world. Body adiposity occurs as a consequence of an imbalance between food intake and energy expenditure. The hypothalamus integrates complex neural and humoral signals that coordinate the initiation and termination...

  • Cellular localization of orexins in human anterior pituitary. Blanco, Montserrat; Gallego, Rosalía; García-Caballero, Tomás; Diéguez, Carlos; Beiras, Andrés // Histochemistry & Cell Biology;Oct2003, Vol. 120 Issue 4, p259 

    Orexins A and B are hypothalamic peptides derived from a precursor called prepro-orexin and are associated with the stimulation of food intake and arousal. There is evidence that orexins act on some pituitary functions. Since no studies have been done concerning the presence of orexins in human...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics