N-labelled pyrazines of triterpenic acids

Vlk, Martin; Micolova, Petra; Urban, Milan; Kvasnica, Miroslav; Saman, David; Sarek, Jan
May 2016
Journal of Radioanalytical & Nuclear Chemistry;May2016, Vol. 308 Issue 2, p733
Academic Journal
Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their N labelled analogs. In this work, we present the synthesis and characterization of the target N labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.


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