F-radiolabeled RGD-A7R-conjugated nano-particles for integrin and VEGF-targeted tumor imaging

Ma, Yufei; Liang, Sheng; Guo, Jun; Wang, Hui
May 2016
Journal of Radioanalytical & Nuclear Chemistry;May2016, Vol. 308 Issue 2, p741
Academic Journal
Radiolabeled RGD-A7R has been extensively investigated for tumor integrin avb3 and VEGF imaging. In this paper, we designed and synthesized a radiolabeled nano-particle that coated with RGD-A7R. The aim of this study was to evaluate if nano-particles has an advantage in vivo kinetics comparing with RGD-A7R monomers. The targeting properties of F- n-BSA-RGD-A7R were tested in U87MG tumor models. The tumor uptake of F- n-BSA-RGD-A7R was high compared with background. The improved pharmacokinetics of F- n-BSA-RGD-A7R confirmed that the application of nano-technology is effective to develop promising imaging agents for the no-invasive detection.


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