TITLE

Different Expression of Sialyl Tn Antigen between Polypoid and Nonpolypoid Growth Types of Advanced Colorectal Carcinoma

AUTHOR(S)
Nakagoe, Tohru; Nanashima, Atsushi; Sawai, Terumitsu; Tuji, Takashi; Yamaguchi, Eiichiro; Jibiki, Masaaki; Yamaguchi, Hiroyuki; Yasutake, Toru; Ayabe, Hiroyoshi; Matuo, Tatsuki; Tagawa, Yutaka
PUB. DATE
August 2000
SOURCE
Oncology;2000, Vol. 59 Issue 2, p131
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Colorectal tumors can be classified based on their growth pattern into the polypoid growth type (PG-type) and nonpolypoid growth type (NPG-type). We examined sialyl Tn antigen expression in advanced colorectal carcinomas that were classified as PG-type and NPG-type cancers in order to ascertain whether or not such expression correlates with other biologically and clinically important differences. A total of 94 advanced colorectal carcinomas were examined for sialyl Tn antigen expression, which was immunohistochemically detected by the monoclonal antibody TKH2. Univariate and multivariate analyses using logistic regression models were performed. Forty carcinomas (42.6%) were negative and 54 (57.5%) were positive for sialyl Tn antigen. Eighteen carcinomas (19.2%) were of PG type and 76 (80.8%) of NPG type. NPG-type cancers had a higher proportion of positive lymph node metastasis than PG-type cancers. Furthermore, sialyl Tn antigen was less often detected in NPG-type cancers (39 of 76; 51.3%) than in PG-type cancers (15 of 18; 83.3%; p = 0.0167). Multivariate analysis showed that two variables, lymph node metastasis and sialyl Tn antigen expression in carcinoma, were independently related to tumor growth patterns, that is NPG type and PG type. These data suggest that the difference in sialyl Tn antigen expression between two kinds of tumor growth patterns of advanced colorectal carcinomas, PG type and NPG type, may reflect different biological behaviors during tumor progression.Copyright © 2000 S. Karger AG, Basel
ACCESSION #
11376155

 

Related Articles

  • Prognostic significance of mucins in colorectal cancer with different DNA mismatch-repair status. Lugli, A.; Zlobec, I.; Baker, K.; Minoo, P.; Tornillo, L.; Terracciano, L.; Jass, J. R. // Journal of Clinical Pathology;May2007, Vol. 60 Issue 5, p534 

    Background: Expression of mucin antigen MUC1 and down regulation of MUC2 are associated with adverse prognosis in colorectal cancer (CRC), but their prognostic significance with respect to differing DNA mismatch repair (MMR) status is poorly understood. Objective: To determine the prognostic...

  • Current treatment of colorectal liver metastases. Tsalis, K.; Vasiliadis, K.; Christoforidis, E.; Vergos, O.; Angelopoulos, S.; Botsios, D.; Betsis, D. // Techniques in Coloproctology;Nov2004 Supplement 1, Vol. 8, ps174 

    Background The aim of our study is to present our experience in the treatment of liver metastases in patients with colorectal cancer. Patients and methods Between 1997 and 2003 a total of 12 patients with liver metastases from a primary colorectal cancer were treated in our department. They were...

  • EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer. Zhu, Shaojun; Chu, Dake; Zhang, Yang; Wang, Xuxia; Gong, Li; Han, Xiujuan; Yao, Li; Lan, Miao; Li, Yanhong; Zhang, Wei // Medical Oncology;Mar2013, Vol. 30 Issue 1, p1 

    EMMPRIN/CD147 has been proved to be associated with tumor invasion and metastasis in various human malignancies. In the present study, we investigated the expression of CD147 and its association with disease-free survival of colorectal cancer patients. CD147 expression was investigated in 328...

  • Hepatic resection for metastasis from colorectal cancer. Ji, Z.-L.; Peng, S.-Y.; Yuan, A.-J.; Li, P.-J.; Zhang, W.; Yu, Y. // Techniques in Coloproctology;Nov2004 Supplement 1, Vol. 8, ps47 

    Background Liver metastases from colorectal cancer are treatable and potentially curable when hepatic resection is applied. This paper is to illustrate surgical treatment of metastatic colorectal cancer in China. Patients and methods Between January 1993 and December 2002, 485 patients with...

  • Molecular Detection of Micrometastases: Science on Stage. Guan, Rong J.; Van Dam, Jacques; Johnson, David // American Journal of Gastroenterology;Oct1999, Vol. 94 Issue 10, p3062 

    Colorectal cancer is the most common gastrointestinal malignancy affecting approximately one person in 20 in the United States. Dissemination of tumor to locoregional lymph nodes is an important prognostic factor. Five-year survival drops from 80% in patients with TNM stage II disease (no...

  • PatohistoloÅ¡ki nalaz kao prognostički faktor ishoda operativnog lečenja karcinoma debelog creva. Sečen, Svetozar; Moljević, Nebojša; Vuković, Milivoje; Somer, Ljiljana // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Aug2010, Vol. 67 Issue 8, p638 

    Background/Aim. Adenocarcinomas of the colon are the most common malignant colorectal tumors. Macroscopic and histopahtological features of colorectal cancer significantly affect its outcome. The aim of this study was to analyze the impact of histopahological finding as a prognostic factor on...

  • Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination. Huang, Dan; Xiang Du; Adachi, Yasushi // World Journal of Gastroenterology;3/28/2008, Vol. 14 Issue 12, p1823 

    Invasion and metastasis are the deadly face of malignant tumors. Considering the high rate of incidence and mortality of colorectal cancer, it is critical to determine the mechanisms of its dissemination. In the parallel investigation of the invasive front and tumor center area of colorectal...

  • Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis. Rodrigues, S.; De Wever, O.; Bruyneel, E.; Rooney, R. J.; Gespach, C. // Oncogene;8/16/2007, Vol. 26 Issue 38, p5615 

    Deleted in colon cancer (DCC) and UNC5 function as netrin dependence receptors by inducing apoptosis in the absence of their ligand and accordingly were recently designated as putative conditional tumor suppressors. Herein, we determined whether netrin-1 and its receptors are implicated in...

  • Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial. Bobe, G.; Murphy, G.; Albert, P. S.; Sansbury, L. B.; Lanza, E.; Schatzkin, A.; Colburn, N. H.; Cross, A. J. // British Journal of Cancer;10/26/2010, Vol. 103 Issue 9, p1453 

    Background: Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics