Kloetzel, Peter-M.
March 2001
Nature Reviews Molecular Cell Biology;Mar2001, Vol. 2 Issue 3, p179
Academic Journal
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes ? the waste-disposal units of the cell ? typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?


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