TITLE

UBIQUITIN AND PROTEASOMES: ANTIGEN PROCESSING BY THE PROTEASOME

AUTHOR(S)
Kloetzel, Peter-M.
PUB. DATE
March 2001
SOURCE
Nature Reviews Molecular Cell Biology;Mar2001, Vol. 2 Issue 3, p179
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes ? the waste-disposal units of the cell ? typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?
ACCESSION #
11359434

 

Related Articles

  • Particulate Systems as Adjuvants and Carriers for Peptide and Protein Antigens. Tao Liang, Ming; Davies, Nigel M.; Blanchfield, Joanne T.; Toth, Istvan // Current Drug Delivery;Oct2006, Vol. 3 Issue 4, p379 

    The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this...

  • A-Kinase Anchoring in Dendritic Cells Is Required for Antigen Presentation. Schillace, Robynn V.; Miller, Casey L.; Pisenti, Neal; Grotzke, Jeff E.; Swarbrick, Gwendolyn M.; Lewinsohn, David M.; Carr, Daniel W. // PLoS ONE;2009, Vol. 4 Issue 3, p1 

    Background: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E2, cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity. In other cells, the ability of these molecules to convey their signals...

  • Immuno-waste exposure and further management. Spaapen, Robbert M; Neefjes, Jacques // Nature Immunology;Feb2012, Vol. 13 Issue 2, p109 

    No abstract available.

  • Stochastic modelling of T-cell activation. Mayer, Hannah; Bovier, Anton // Journal of Mathematical Biology;Jan2015, Vol. 70 Issue 1/2, p99 

    We investigate a specific part of the human immune system, namely the activation of T-cells, using stochastic tools, especially sharp large deviation results. T-cells have to distinguish reliably between foreign and self peptides which are both presented to them by antigen presenting cells. Our...

  • Antigen-presenting Cells.  // Encyclopedic Reference of Molecular Pharmacology;2004, p75 

    An encyclopedia entry for the term "antigen-presenting cells," which refers to cells of the immune system that are able to process and present foreign antigens to effector cells.

  • Regulation of MHC class II-peptide complex expression by ubiquitination. Kyung-Jin Cho; Roche, Paul A. // Frontiers in Immunology;Nov2013, Vol. 4, p1 

    MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4+ T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has...

  • IKK2.  // Encyclopedic Reference of Cancer;2001, p444 

    An encyclopedia entry for "IKK2" is presented. It stands for inhibitor of K light polypeptide gene enhancer in B cells, kinase 1. Synonyms are IKK Î’ or inhibitor of K light polypeptide gene enhancer in B cells, kinase Î’, NFKBIKB and IKBKB or inhibitor of K light polypeptide gene enhancer...

  • T cell receptors and immunoregulation. Rayfield, Lee S. // Journal of the Royal Society of Medicine;Dec1985, Vol. 78 Issue 12, p1056 

    The article offers information regarding the receptor for antigen on T lymphocytes (Tr). The amino acid of the Tr has been analyzed either by proteolytic digestion and peptide mapping. The approach has yielded a great deal of information regarding the organization of the Tr genes. Unlike B...

  • One Little Kitten (Book). Kouzel, Daisy // School Library Journal;Sep79, Vol. 26 Issue 1, p112 

    Reviews the book 'One Little Kitten,' by Tana Hoban.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics