TITLE

UBIQUITIN AND PROTEASOMES: SUMO, UBIQUITIN'S MYSTERIOUS COUSIN

AUTHOR(S)
Müller, Stefan; Hoege, Carsten; Pyrowolakis, George; Jentsch, Stefan
PUB. DATE
March 2001
SOURCE
Nature Reviews Molecular Cell Biology;Mar2001, Vol. 2 Issue 3, p202
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.
ACCESSION #
11359431

 

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