TITLE

Multicentre European study of thalamic stimulation in essential tremor: a six year follow up

AUTHOR(S)
Sydow O; Thobois S; Alesch F; Speelman J D
PUB. DATE
October 2003
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Oct2003, Vol. 74 Issue 10, p1387
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND: Thalamic stimulation is an efficient treatment for disabling essential tremor, as previously shown, but follow up has mostly been short term. OBJECTIVES: To see whether good results can be maintained in the longer term. METHODS: 37 patients with essential tremor had implantation of a thalamic stimulator, either unilaterally or bilaterally. The results at one year have been reported earlier. After six years, 19 patients were available for follow up. The main instrument for evaluation was the essential tremor rating scale. The patients were examined with pulse generators turned on and off. RESULTS: In the majority of patients, the very good results with stimulation seen at one year were maintained after a mean of 6.5 years. The reduction in tremor scores and improvement in activities of daily living were highly significant compared with baseline and with the stimulation turned off. There were few serious adverse events. Minor side effects related to stimulation were common. Few device related complications were observed and most could be resolved. CONCLUSIONS: Good reduction in tremor can be maintained for more than six years in the majority of these severely disabled patients. Thalamic stimulation can be recommended in essential tremor where there is insufficient response to drug treatment. Surgical procedures and follow up should be concentrated in relatively few centres, which will thereby acquire a high degree of expertise.
ACCESSION #
11352990

 

Related Articles

  • Thalamic Deep Brain Stimulation for Essential Tremor: Recommendations for Long-Term Outcome Analysis. Putzke, J.D.; Wharen Jr., R.E.; Obwegeser, A.A.; Wszolek, Z.K.; Lucas, J.A.; Turk, M.F.; Uitti, R.J. // Canadian Journal of Neurological Sciences;Aug2004, Vol. 31 Issue 3, p333 

    Examines the efficacy of thalamic deep brain stimulation (DBS) for tremor control among individuals with essential tremor (ET). Association of stimulation with significant improvement at nearly every postoperative interval as compared to pre-operative and stimulation "off" ratings of activities...

  • Movement Disorders and Neuromodulation. Shipton, Edward A. // Neurology Research International;2012, p1 

    Movement disorders are neurological conditions affecting speed, fluency, quality, and ease of movement. Deep brain stimulation (DBS) is used to treat advanced Parkinson's disease, essential tremor, and dystonia. Possible target sites for DBS include the ventral intermediate nucleus of the...

  • Brain Pain. Bradley, Ryan // Popular Science;Mar2012, Vol. 280 Issue 3, p34 

    The article discusses migraines, examining research on their causes and possible treatments or cures. The author looks at research by neurologist David Dodick on the role of the thalamus in the transmission of pain as well as a subcutaneous battery which uses neurostimulation to disrupt pain...

  • A model for simulating Local Field Potential in the thalamus of Essential Tremor patient during deep brain stimulation. Basu, Ishita; Tuninetti, Daniela; Graupe, Daniel; Slavin, Konstantin V. // BMC Neuroscience;2012 Supplement 1, Vol. 13 Issue Suppl 1, p1 

    An abstract of the article "A model for simulating Local Field Potential in the thalamus of Essential Tremor patient during deep brain stimulation," by Ishita Basu, Daniela Tuninetti, Daniel Graupe and Konstantin V. Slavin is presented.

  • Dynamic networking. Barton, Samantha // Nature Reviews Neuroscience;Feb2006, Vol. 7 Issue 2, p90 

    Discusses research being done on the response of primary sensory corticles to thalamic stimulation. Reference to a study by J. N. MacLean, et al, in the 2005 issue of "Neuron"; Results of calcium imaging of layer 4 cortical neurons; Comparison between cortical and spontaneous activity.

  • Epilepsy patients see 68% fewer seizures with Medtronic's therapy. YOFFEE, LYNN // Medical Device Daily;12/9/2009, Vol. 13 Issue 236, p1 

    This article deals with a study that examined the use of deep brain stimulation (DBS) in treating epilepsy. Results of the study showed that DBS therapy led to a 68% reduction in seizure frequency among patients. Particular focus is given to how DBS therapy works. Patients with medically...

  • Stuttering induced by thalamic deep brain stimulation for dystonia. Allert, Niels; Kelm, Daniela; Blahak, Christian; Capelle, Hans-Holger; Krauss, Joachim K. // Journal of Neural Transmission;May2010, Vol. 117 Issue 5, p617 

    We report a patient in whom deep brain stimulation of the ventral intermediate nucleus of the thalamus (Vim) for treating dystonia reversibly induced stuttering at suboptimal stimulation parameters. Adjustments of stimulation parameters resulted in excellent control of dystonic motor symptoms...

  • Deep brain stimulation in the treatment of severe dystonia. Vercueil, Laurent; Pollak, Pierre; Fraix, Valérie; Caputo, Elena; Moro, Elena; Benazzouz, Abdelhamid; Xie, Jing; Koudsie, Adnan; Benabid, Alim-Louis // Journal of Neurology;Aug2001, Vol. 248 Issue 8, p695 

    A retrospective study of a consecutive series of 19 patients with medically intractable dystonia treated with uni- or bilateral deep brain stimulation (DBS) is reported. A minimal follow-up of 6 months was available, up to eleven years in one patient. The first twelve consecutive patients (4...

  • Reversible acute cognitive dysfunction induced by bilateral STN stimulation. Cakmakli, Gul Yulcin; Oruckaptan, Hakan; Saka, Esen; Elibol, Bulent // Journal of Neurology;Aug2009, Vol. 256 Issue 8, p1360 

    Deep brain stimulation of the subthalamic nucleus (STN) is an effective treatment modality for motor symptoms of advanced Parkinson’s disease. Recent studies focus on exploring its possible effects on cognition and behavior. We present a case with acute cognitive dysfunction due to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics